The application of emerging knowledge is crucial for innovation by firms competing in science and technology-intensive industries. However, relatively little is known about how and where firms search externally for emerging knowledge. This study investigates collaborative and geographic proximate search patterns and the use of emergent knowledge in innovation activities. The examination of patent references in the US biotechnology industry reveals significant differences among knowledge-search patterns. Collaborative search relates to emerging knowledge, but the age of the knowledge increases with geographic distance because knowledge sourced internationally tends to be older than national or local knowledge.