TY - JOUR
T1 - Robustness of frequency vs. amplitude coding of calcium oscillations during changing temperatures
AU - Aguilera, Luis
AU - Bergmann, Frank T.
AU - Dalmasso, Giovanni
AU - Elmas, Sinan
AU - Elsässer, Tobias
AU - Großeholz, Ruth
AU - Holzheu, Pascal
AU - Kalra, Priyata
AU - Kummer, Ursula
AU - Sahle, Sven
AU - Veith, Nadine
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/2
Y1 - 2019/2
N2 - Intracellular calcium oscillations have been widely studied. It is assumed that information is conveyed in the frequency, amplitude and shape of these oscillations. In particular, calcium signalling in mammalian liver cells has repeatedly been reported to display frequency coding so that an increasing amount of stimulus is translated into an increasing frequency of the oscillations. However, recently, we have shown that calcium oscillations in fish liver cells rather exhibit amplitude coding with increasing stimuli being translated into increasing amplitudes. Practical consequences of this difference are unknown so far. Here we investigated advantages and disadvantages of frequency vs. amplitude coding, in particular in environments with substantially changing temperatures (e.g. 10–20 degrees). For this purpose, we use computational modelling and a new approach to generate a calcium model exactly displaying a specific frequency and/or amplitude. We conclude that despite the advantages in flexibility that frequencies might offer for the transmission of information in the cell, amplitude coding is obviously more robust with respect to changes in environmental temperatures. This potentially explains the observed differences between two classes of organisms, one operating at constant temperatures whereas the other is not.
AB - Intracellular calcium oscillations have been widely studied. It is assumed that information is conveyed in the frequency, amplitude and shape of these oscillations. In particular, calcium signalling in mammalian liver cells has repeatedly been reported to display frequency coding so that an increasing amount of stimulus is translated into an increasing frequency of the oscillations. However, recently, we have shown that calcium oscillations in fish liver cells rather exhibit amplitude coding with increasing stimuli being translated into increasing amplitudes. Practical consequences of this difference are unknown so far. Here we investigated advantages and disadvantages of frequency vs. amplitude coding, in particular in environments with substantially changing temperatures (e.g. 10–20 degrees). For this purpose, we use computational modelling and a new approach to generate a calcium model exactly displaying a specific frequency and/or amplitude. We conclude that despite the advantages in flexibility that frequencies might offer for the transmission of information in the cell, amplitude coding is obviously more robust with respect to changes in environmental temperatures. This potentially explains the observed differences between two classes of organisms, one operating at constant temperatures whereas the other is not.
KW - Calcium oscillations
KW - Decoding
KW - Hepatocytes
KW - Temperature dependence
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UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000457949300004&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1016/j.bpc.2018.11.003
DO - 10.1016/j.bpc.2018.11.003
M3 - Article
C2 - 30529877
AN - SCOPUS:85057817409
SN - 0301-4622
VL - 245
SP - 17
EP - 24
JO - Biophysical Chemistry
JF - Biophysical Chemistry
ER -