TY - JOUR
T1 - RISK score for developing ventilator-associated pneumonia in children
T2 - The RISVAP study
AU - Girona-Alarcón, Mònica
AU - Bobillo-Perez, Sara
AU - Solé-Ribalta, Anna
AU - Cuadras, Daniel
AU - Guitart, Carmina
AU - Balaguer, Mònica
AU - Cambra, Francisco José
AU - Jordan, Iolanda
N1 - Funding Information:
No funding was received for this study.
Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/7
Y1 - 2022/7
N2 - Objectives: Ventilator-associated pneumonia (VAP) is the second most common healthcare-associated infection in children. The aim of this study was to determine the risk factors for VAP in children and to create a risk score for developing VAP (RISVAP score). Study design: It was a prospective observational study, including children who required mechanical ventilation (MV), registered in the multicentre ENVIN-HELICS database from 2014 to 2019. The regression coefficients of each independent risk factor for VAP were used to create the RISVAP score. Each factor scored 0 if it was absent, or, if it was present, an assigned value from 1 to 7, according to the regression coefficient. Results: A total of 3798 patients were included, 97(2.5%) developing VAP. The independent risk factors for VAP were: female (odds ratio [OR]: 1.642, p = 0.024), MV > 4 days (OR: 26.79, p < 0.001), length in pediatric intensive care unit > 7 days (OR: 11.74, p < 0.001), and previous colonisation (OR: 4.18, p < 0.001). The RISVAP was calculated for each patient as the sum of all the independent risk factors. Three risk groups were obtained: low (0–5 points), intermediate (6–12 points), and high risk for VAP (13–16 points). The area under the curve for the final score was 0.905 (95%confidence interval: 0.888–0.923, p < 0.001). Conclusions: The RISVAP is the first risk score for VAP in pediatric populations. Using this predictive score, might be helpful to detect vulnerable patients and therefore implement preventative strategies.
AB - Objectives: Ventilator-associated pneumonia (VAP) is the second most common healthcare-associated infection in children. The aim of this study was to determine the risk factors for VAP in children and to create a risk score for developing VAP (RISVAP score). Study design: It was a prospective observational study, including children who required mechanical ventilation (MV), registered in the multicentre ENVIN-HELICS database from 2014 to 2019. The regression coefficients of each independent risk factor for VAP were used to create the RISVAP score. Each factor scored 0 if it was absent, or, if it was present, an assigned value from 1 to 7, according to the regression coefficient. Results: A total of 3798 patients were included, 97(2.5%) developing VAP. The independent risk factors for VAP were: female (odds ratio [OR]: 1.642, p = 0.024), MV > 4 days (OR: 26.79, p < 0.001), length in pediatric intensive care unit > 7 days (OR: 11.74, p < 0.001), and previous colonisation (OR: 4.18, p < 0.001). The RISVAP was calculated for each patient as the sum of all the independent risk factors. Three risk groups were obtained: low (0–5 points), intermediate (6–12 points), and high risk for VAP (13–16 points). The area under the curve for the final score was 0.905 (95%confidence interval: 0.888–0.923, p < 0.001). Conclusions: The RISVAP is the first risk score for VAP in pediatric populations. Using this predictive score, might be helpful to detect vulnerable patients and therefore implement preventative strategies.
KW - healthcare-associated infection
KW - intensive care
KW - pediatrics
KW - ventilator-associated pneumonia
UR - http://www.scopus.com/inward/record.url?scp=85128757351&partnerID=8YFLogxK
U2 - 10.1002/ppul.25929
DO - 10.1002/ppul.25929
M3 - Article
C2 - 35434973
AN - SCOPUS:85128757351
SN - 8755-6863
VL - 57
SP - 1635
EP - 1642
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 7
ER -