RISK score for developing ventilator-associated pneumonia in children: The RISVAP study

Mònica Girona-Alarcón, Sara Bobillo-Perez, Anna Solé-Ribalta, Daniel Cuadras, Carmina Guitart, Mònica Balaguer, Francisco José Cambra, Iolanda Jordan

Producció científica: Article en revista indexadaArticleAvaluat per experts


Objectives: Ventilator-associated pneumonia (VAP) is the second most common healthcare-associated infection in children. The aim of this study was to determine the risk factors for VAP in children and to create a risk score for developing VAP (RISVAP score). Study design: It was a prospective observational study, including children who required mechanical ventilation (MV), registered in the multicentre ENVIN-HELICS database from 2014 to 2019. The regression coefficients of each independent risk factor for VAP were used to create the RISVAP score. Each factor scored 0 if it was absent, or, if it was present, an assigned value from 1 to 7, according to the regression coefficient. Results: A total of 3798 patients were included, 97(2.5%) developing VAP. The independent risk factors for VAP were: female (odds ratio [OR]: 1.642, p = 0.024), MV > 4 days (OR: 26.79, p < 0.001), length in pediatric intensive care unit > 7 days (OR: 11.74, p < 0.001), and previous colonisation (OR: 4.18, p < 0.001). The RISVAP was calculated for each patient as the sum of all the independent risk factors. Three risk groups were obtained: low (0–5 points), intermediate (6–12 points), and high risk for VAP (13–16 points). The area under the curve for the final score was 0.905 (95%confidence interval: 0.888–0.923, p < 0.001). Conclusions: The RISVAP is the first risk score for VAP in pediatric populations. Using this predictive score, might be helpful to detect vulnerable patients and therefore implement preventative strategies.

Idioma originalAnglès
Pàgines (de-a)1635-1642
Nombre de pàgines8
RevistaPediatric Pulmonology
Estat de la publicacióPublicada - de jul. 2022
Publicat externament


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