TY - JOUR
T1 - Regulation of plant stem cell quiescence by a brassinosteroid signaling module
AU - Vilarrasa-Blasi, Josep
AU - González-García, Mary Paz
AU - Frigola, David
AU - Fàbregas, Norma
AU - Alexiou, Konstantinos G.
AU - López-Bigas, Nuria
AU - Rivas, Susana
AU - Jauneau, Alain
AU - Lohmann, Jan U.
AU - Benfey, Philip N.
AU - Ibañes, Marta
AU - Caño-Delgado, Ana I.
PY - 2014/7/14
Y1 - 2014/7/14
N2 - The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO invivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.
AB - The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO invivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.
UR - http://www.scopus.com/inward/record.url?scp=84904316605&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2014.05.020
DO - 10.1016/j.devcel.2014.05.020
M3 - Article
C2 - 24981610
AN - SCOPUS:84904316605
SN - 1534-5807
VL - 30
SP - 36
EP - 47
JO - Developmental Cell
JF - Developmental Cell
IS - 1
ER -