TY - JOUR
T1 - Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders
AU - Kałafut, Joanna
AU - Czerwonka, Arkadiusz
AU - Czapla, Karolina
AU - Przybyszewska-Podstawka, Alicja
AU - Hermanowicz, Justyna Magdalena
AU - Rivero-Müller, Adolfo
AU - Borkiewicz, Lidia
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at the transcriptional level but also by a variety of post-translational events. First is the ligand-dependent mechanical activation of NOTCH receptors and then the intracellular crosstalk with other signalling molecules—among those are long non-coding RNAs (lncRNAs). In this review, we provide a detailed overview of the specific role of lncRNAs in the modulation of Notch1 signalling, from expression to activity, and their connection with the development of health disorders, especially cancers.
AB - Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at the transcriptional level but also by a variety of post-translational events. First is the ligand-dependent mechanical activation of NOTCH receptors and then the intracellular crosstalk with other signalling molecules—among those are long non-coding RNAs (lncRNAs). In this review, we provide a detailed overview of the specific role of lncRNAs in the modulation of Notch1 signalling, from expression to activity, and their connection with the development of health disorders, especially cancers.
KW - cancer
KW - lncRNA
KW - microRNA
KW - NOTCH
KW - Notch signalling
UR - https://www.scopus.com/pages/publications/85168900167
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:001056756400001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.3390/ijms241612579
DO - 10.3390/ijms241612579
M3 - Review
AN - SCOPUS:85168900167
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 16
M1 - 12579
ER -
