TY - JOUR
T1 - Regioselective symmetrical bromination of protected 2,2′-biimidazole
AU - Sánchez-García, David
AU - Borrós, Salvador
AU - Nonell, Santi
AU - Borrell, José I.
AU - Colominas, Carles
AU - Teixidó, Jordi
PY - 2002
Y1 - 2002
N2 - Treatment of the benzyl and (trimethylsilylethoxymethyl) SEM protected 2,2′-biimidazoles, 2a and 2b, with 2 equivalents of N-bromosuccinimide (NBS) allows obtaining the 5,5′-dibromo and 4,4′-dibromo substituted biimidazoles, 3a and 5b respectively. The use of 4 equivalents of NBS, followed by treatment of the corresponding tetrabromoderivatives 4a and 5b with butyl lithium (BuLi), yields the 4,4′-dibromoderivatives 5a (G=Bn) and 5b (G=SEM).
AB - Treatment of the benzyl and (trimethylsilylethoxymethyl) SEM protected 2,2′-biimidazoles, 2a and 2b, with 2 equivalents of N-bromosuccinimide (NBS) allows obtaining the 5,5′-dibromo and 4,4′-dibromo substituted biimidazoles, 3a and 5b respectively. The use of 4 equivalents of NBS, followed by treatment of the corresponding tetrabromoderivatives 4a and 5b with butyl lithium (BuLi), yields the 4,4′-dibromoderivatives 5a (G=Bn) and 5b (G=SEM).
UR - http://www.scopus.com/inward/record.url?scp=0036666319&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000177407600018&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1002/jhet.5570390418
DO - 10.1002/jhet.5570390418
M3 - Article
AN - SCOPUS:0036666319
SN - 0022-152X
VL - 39
SP - 733
EP - 735
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 4
ER -