Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol

Pilar Abós; Carme Artigas; Sonia Bertolotti; Silvia E. Braslavsky; Pere Fors; Kamil Lang; Santi Nonell; Francisco J. Rodríguez; Maria L. Sesé; Francesc R. Trull

doi:10.1016/S1011-1344(97)00080-8

Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol

Pilar Abós, Carme Artigas, Sonia Bertolotti, Silvia E. Braslavsky, Pere Fors, Kamil Lang, Santi Nonell^*, Francisco J. Rodríguez, Maria L. Sesé, Francesc R. Trull

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The photophysical and singlet molecular oxygen photosensitizing properties of two amphiphilic systems consisting of mesoporphyrin bound to one polyoxyethylene chain through ester or amide bonds (MPEGE and MPEGA, respectively) have been determined in aqueous and organic solvents. Steady-state and time-resolved UV-Vis-NIR absorption and emission, as well as chemical trapping studies indicate that both systems are essentially monomeric in CH₂Cl₂, their properties resembling those of mesoporphyrin dimethyl ester. In aqueous solutions the photoproperties show a remarkable dependence on the concentration which is attributed to aggregation phenomena. Below 10 μM the process can be described as a monomer-dimer equilibrium with constant K = (1.6 ± 0.5) X 10⁶ in water. The absorption, fluorescence, and singlet oxygen production characteristics of both monomer and dimer have been determined.

Idioma original	Anglès
Pàgines (de-a)	53-59
Nombre de pàgines	7
Revista	Journal of Photochemistry and Photobiology, B: Biology
Volum	41
Número	1-2
DOIs	https://doi.org/10.1016/S1011-1344(97)00080-8
Estat de la publicació	Publicada - de nov. 1997

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Abós, P., Artigas, C., Bertolotti, S., Braslavsky, S. E., Fors, P., Lang, K., Nonell, S., Rodríguez, F. J., Sesé, M. L., & Trull, F. R. (1997). Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol. Journal of Photochemistry and Photobiology, B: Biology, 41(1-2), 53-59. https://doi.org/10.1016/S1011-1344(97)00080-8

@article{af7de6a20b6c433297b51643c1edb46c,

title = "Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol",

abstract = "The photophysical and singlet molecular oxygen photosensitizing properties of two amphiphilic systems consisting of mesoporphyrin bound to one polyoxyethylene chain through ester or amide bonds (MPEGE and MPEGA, respectively) have been determined in aqueous and organic solvents. Steady-state and time-resolved UV-Vis-NIR absorption and emission, as well as chemical trapping studies indicate that both systems are essentially monomeric in CH2Cl2, their properties resembling those of mesoporphyrin dimethyl ester. In aqueous solutions the photoproperties show a remarkable dependence on the concentration which is attributed to aggregation phenomena. Below 10 μM the process can be described as a monomer-dimer equilibrium with constant K = (1.6 ± 0.5) X 106 in water. The absorption, fluorescence, and singlet oxygen production characteristics of both monomer and dimer have been determined.",

keywords = "Aggregation, Amphiphilic, Fluorescence, Photodynamic, Polyethylene glycol, Porphyrin, Singlet molecular oxygen",

author = "Pilar Ab{\'o}s and Carme Artigas and Sonia Bertolotti and Braslavsky, {Silvia E.} and Pere Fors and Kamil Lang and Santi Nonell and Rodr{\'i}guez, {Francisco J.} and Ses{\'e}, {Maria L.} and Trull, {Francesc R.}",

year = "1997",

month = nov,

doi = "10.1016/S1011-1344(97)00080-8",

language = "English",

volume = "41",

pages = "53--59",

journal = "Journal of Photochemistry and Photobiology, B: Biology",

issn = "1011-1344",

publisher = "Elsevier B.V.",

number = "1-2",

}

Abós, P, Artigas, C, Bertolotti, S, Braslavsky, SE, Fors, P, Lang, K, Nonell, S, Rodríguez, FJ, Sesé, ML & Trull, FR 1997, 'Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol', Journal of Photochemistry and Photobiology, B: Biology, vol. 41, núm. 1-2, pàg. 53-59. https://doi.org/10.1016/S1011-1344(97)00080-8

Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol. / Abós, Pilar; Artigas, Carme; Bertolotti, Sonia et al.
In: Journal of Photochemistry and Photobiology, B: Biology, Vol. 41, Núm. 1-2, 11.1997, pàg. 53-59.

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TY - JOUR

T1 - Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol

AU - Abós, Pilar

AU - Artigas, Carme

AU - Bertolotti, Sonia

AU - Braslavsky, Silvia E.

AU - Fors, Pere

AU - Lang, Kamil

AU - Nonell, Santi

AU - Rodríguez, Francisco J.

AU - Sesé, Maria L.

AU - Trull, Francesc R.

PY - 1997/11

Y1 - 1997/11

N2 - The photophysical and singlet molecular oxygen photosensitizing properties of two amphiphilic systems consisting of mesoporphyrin bound to one polyoxyethylene chain through ester or amide bonds (MPEGE and MPEGA, respectively) have been determined in aqueous and organic solvents. Steady-state and time-resolved UV-Vis-NIR absorption and emission, as well as chemical trapping studies indicate that both systems are essentially monomeric in CH2Cl2, their properties resembling those of mesoporphyrin dimethyl ester. In aqueous solutions the photoproperties show a remarkable dependence on the concentration which is attributed to aggregation phenomena. Below 10 μM the process can be described as a monomer-dimer equilibrium with constant K = (1.6 ± 0.5) X 106 in water. The absorption, fluorescence, and singlet oxygen production characteristics of both monomer and dimer have been determined.

AB - The photophysical and singlet molecular oxygen photosensitizing properties of two amphiphilic systems consisting of mesoporphyrin bound to one polyoxyethylene chain through ester or amide bonds (MPEGE and MPEGA, respectively) have been determined in aqueous and organic solvents. Steady-state and time-resolved UV-Vis-NIR absorption and emission, as well as chemical trapping studies indicate that both systems are essentially monomeric in CH2Cl2, their properties resembling those of mesoporphyrin dimethyl ester. In aqueous solutions the photoproperties show a remarkable dependence on the concentration which is attributed to aggregation phenomena. Below 10 μM the process can be described as a monomer-dimer equilibrium with constant K = (1.6 ± 0.5) X 106 in water. The absorption, fluorescence, and singlet oxygen production characteristics of both monomer and dimer have been determined.

KW - Aggregation

KW - Amphiphilic

KW - Fluorescence

KW - Photodynamic

KW - Polyethylene glycol

KW - Porphyrin

KW - Singlet molecular oxygen

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U2 - 10.1016/S1011-1344(97)00080-8

DO - 10.1016/S1011-1344(97)00080-8

M3 - Article

AN - SCOPUS:0039752415

SN - 1011-1344

VL - 41

SP - 53

EP - 59

JO - Journal of Photochemistry and Photobiology, B: Biology

JF - Journal of Photochemistry and Photobiology, B: Biology

IS - 1-2

ER -

Abós P, Artigas C, Bertolotti S, Braslavsky SE, Fors P, Lang K et al. Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol. Journal of Photochemistry and Photobiology, B: Biology. 1997 nov.;41(1-2):53-59. doi: 10.1016/S1011-1344(97)00080-8

Polymer bound pyrrole compounds, IX. Photophysical and singlet molecular oxygen photosensitizing properties of mesoporphyrin IX covalently bound to a low molecular weight polyethylene glycol

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