Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition

Anna Łuczyńska, Rudolf Kaaks, Sabine Rohrmann, Susen Becker, Jakob Linseisen, Brian Buijsse, Kim Overvad, Antonia Trichopoulou, Elisavet Valanou, Antonia Barmpitsioti, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Salvatore Panico, H. Bas Bueno-de-Mesquita, Fränzel J.B. Van Duijnhoven, Petra H.M. Peeters, Roel Vermeulen, Elisabete Weiderpass, Magritt BrustadGuri Skeie, Carlos A. González, Paula Jakszyn, J. Ramón Quirós, María José Sánchez, José María Huerta, Eva Ardanaz, Beatrice Melin, Ann Sofie Johansson, Martin Almquist, Johan Malm, Kay Tee Khaw, Nick Wareham, Ruth C. Travis, Veronika Fedirko, Isabelle Romieu, Mazda Jenab, Valentina Gallo, Elio Riboli, Paolo Vineis, Alexandra Nieters

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Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and seasonspecific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (Pheterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with ≥2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

Idioma originalAnglès
Pàgines (de-a)827-838
Nombre de pàgines12
RevistaAmerican Journal of Clinical Nutrition
Estat de la publicacióPublicada - 1 de set. 2013
Publicat externament


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