TY - JOUR
T1 - PIFs
T2 - Systems integrators in plant development
AU - Leivar, Pablo
AU - Monte, Elena
PY - 2014/1
Y1 - 2014/1
N2 - Phytochrome-interacting factors (PIFs) are members of the Arabidopsis thaliana basic helix-loop-helix family of transcriptional regulators that interact specifically with the active Pfr conformer of phytochrome (phy) photoreceptors. PIFs are central regulators of photomorphogenic development that act to promote stem growth, and this activity is reversed upon interaction with phy in response to light. Recently, significant progress has been made in defining the transcriptional networks directly regulated by PIFs, as well as the convergence of other signaling pathways on the PIFs to modulate growth. Here, we summarize and highlight these findings in the context of PIFs acting as integrators of light and other signals. We discuss progress in our understanding of the transcriptional and posttranslational regulation of PIFs that illustrates the integration of light with hormonal pathways and the circadian clock, and we review seedling hypocotyl growth as a paradigm of PIFs acting at the interface of these signals. Based on these advances, PIFs are emerging as required factors for growth, acting as central components of a regulatory node that integrates multiple internal and external signals to optimize plant development.
AB - Phytochrome-interacting factors (PIFs) are members of the Arabidopsis thaliana basic helix-loop-helix family of transcriptional regulators that interact specifically with the active Pfr conformer of phytochrome (phy) photoreceptors. PIFs are central regulators of photomorphogenic development that act to promote stem growth, and this activity is reversed upon interaction with phy in response to light. Recently, significant progress has been made in defining the transcriptional networks directly regulated by PIFs, as well as the convergence of other signaling pathways on the PIFs to modulate growth. Here, we summarize and highlight these findings in the context of PIFs acting as integrators of light and other signals. We discuss progress in our understanding of the transcriptional and posttranslational regulation of PIFs that illustrates the integration of light with hormonal pathways and the circadian clock, and we review seedling hypocotyl growth as a paradigm of PIFs acting at the interface of these signals. Based on these advances, PIFs are emerging as required factors for growth, acting as central components of a regulatory node that integrates multiple internal and external signals to optimize plant development.
KW - Phytochrome-interacting factors
KW - Arabidopsis circadian clock
KW - Helix transcription factor
KW - Light-signal-transduction
KW - Genome-wide identification
KW - Shade-avoidance-response
KW - Red elongated hypocotyl1
KW - Apical hook development
KW - Seed-germination
KW - Negative regulator
UR - http://www.scopus.com/inward/record.url?scp=84896832547&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000332223200008&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1105/tpc.113.120857
DO - 10.1105/tpc.113.120857
M3 - Review
C2 - 24481072
AN - SCOPUS:84896832547
SN - 1040-4651
VL - 26
SP - 56
EP - 78
JO - Plant Cell
JF - Plant Cell
IS - 1
ER -