TY - CHAP
T1 - Photosensitisers for photodynamic therapy: State of the art and perspectives
AU - Rodríguez Amigo, Beatriz
AU - Planas Marques, Oriol
AU - Bresoli Obach, Roger
AU - Torra Nonell, Joaquim
AU - Ruiz Gonzalez, Ruben
AU - Nonell Marrugat, Santiago
N1 - Rodríguez-Amigo, B.; Planas, O.; Bresolí-Obach, R.; Torra, J.; Ruiz-González, R.; Nonell, S.
PY - 2016
Y1 - 2016
N2 - Photodynamic therapy relies on the action of a photosensitising drug in order to generate reactive oxygen species that cause damage to biological cells and tissues. The key aspects for the success of this therapy are the optical and photosensitising properties of the drug, as well as its pharmacological properties. This chapter provides an overview of the drugs already approved for clinical use for cancer, antimicrobial or other applications, as well as a list of those in clinical trials and at the preclinical stage. Emerging strategies for controlling the production of reactive oxygen species and novel photosensitising modalities brought about by the bio- and nano-revolutions are discussed.
AB - Photodynamic therapy relies on the action of a photosensitising drug in order to generate reactive oxygen species that cause damage to biological cells and tissues. The key aspects for the success of this therapy are the optical and photosensitising properties of the drug, as well as its pharmacological properties. This chapter provides an overview of the drugs already approved for clinical use for cancer, antimicrobial or other applications, as well as a list of those in clinical trials and at the preclinical stage. Emerging strategies for controlling the production of reactive oxygen species and novel photosensitising modalities brought about by the bio- and nano-revolutions are discussed.
KW - Singlet-oxygen generation
KW - Near-infrared photoimmunotherapy
KW - Aggregation-induced emission
KW - Walled carbon nanotubes
KW - Genetically-encoded photosensitizer
KW - Targeting cancer-cells
KW - Collagen cross-linking
KW - Growth-factor receptor
KW - Icg laser therapy
KW - Fluorescent protein
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000404988300003&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1039/9781782626824-00023
DO - 10.1039/9781782626824-00023
M3 - Chapter
SN - 978-1-78262-451-6
T3 - Comprehensive Series in Photochemical & Photobiological Sciences
SP - 23
EP - 62
BT - Photodynamic Medicine: From bench to clinic
A2 - Kostron, Herwig
A2 - Hasan, Tayyaba
PB - Royal Society of Chemistry
ER -