Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Eduardo Anaya-Plaza, Eveline van de Winckel, Joona Mikkilä, Jani Markus Malho, Olli Ikkala, Oscar Gulías, Roger Bresolí-Obach, Montserrat Agut, Santi Nonell, Tomás Torres, Mauri A. Kostiainen, Andrés de la Escosura

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Resum

The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.

Idioma originalAnglès
Pàgines (de-a)4320-4326
Nombre de pàgines7
RevistaChemistry - A European Journal
Volum23
Número18
DOIs
Estat de la publicacióPublicada - 28 de març 2017

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