TY - JOUR
T1 - Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals
AU - Anaya-Plaza, Eduardo
AU - van de Winckel, Eveline
AU - Mikkilä, Joona
AU - Malho, Jani Markus
AU - Ikkala, Olli
AU - Gulías, Oscar
AU - Bresolí-Obach, Roger
AU - Agut, Montserrat
AU - Nonell, Santi
AU - Torres, Tomás
AU - Kostiainen, Mauri A.
AU - de la Escosura, Andrés
N1 - Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/3/28
Y1 - 2017/3/28
N2 - The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.
AB - The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.
KW - cellulose nanocrystals
KW - functional materials
KW - photoantimicrobial biohybrids
KW - phthalocyanine
KW - supramolecular complex
UR - http://www.scopus.com/inward/record.url?scp=85016262812&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000399314800013&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1002/chem.201605285
DO - 10.1002/chem.201605285
M3 - Article
C2 - 28097714
AN - SCOPUS:85016262812
SN - 0947-6539
VL - 23
SP - 4320
EP - 4326
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 18
ER -