PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

Raúl  Cosialls Menárguez; Cristina Simó; Salvador Borrós; Vanessa Gómez-Vallejo; Claudia Schmidt; Jordi Llop; Ana B. Cuenca; Angela Casini

doi:10.1002/chem.202202604

PET Imaging of Self-Assembled ¹⁸F-Labelled Pd₂L₄ Metallacages for Anticancer Drug Delivery

Raúl Cosialls Menárguez
, Cristina Simó
, Salvador Borrós
, Vanessa Gómez-Vallejo
, Claudia Schmidt
, Jordi Llop^*
, Ana B. Cuenca^*
, Angela Casini^*

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

21 Citacions (Web of Science)

Resum

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of ¹⁸F-labelled [Pd₂L₄]⁴⁺ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Idioma original	Anglès
Número d’article	e202202604
Nombre de pàgines	8
Revista	Chemistry - A European Journal
Volum	29
Número	3
DOIs	https://doi.org/10.1002/chem.202202604
Estat de la publicació	Publicada - 12 de gen. 2023

Accés al document

10.1002/chem.202202604Llicència: CC BY

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@article{ce10c82629984a43ad14108c84b9a33b,

title = "PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery",

abstract = "To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.",

keywords = "PET imaging, ammonium trifluoroborates, cisplatin, drug delivery, metallacages, self-assembly",

author = "\{Cosialls Men{\'a}rguez\}, Ra{\'u}l and Cristina Sim{\'o} and Salvador Borr{\'o}s and Vanessa G{\'o}mez-Vallejo and Claudia Schmidt and Jordi Llop and Cuenca, \{Ana B.\} and Angela Casini",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.",

year = "2023",

month = jan,

day = "12",

doi = "10.1002/chem.202202604",

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TY - JOUR

T1 - PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

AU - Cosialls Menárguez, Raúl

AU - Simó, Cristina

AU - Borrós, Salvador

AU - Gómez-Vallejo, Vanessa

AU - Schmidt, Claudia

AU - Llop, Jordi

AU - Cuenca, Ana B.

AU - Casini, Angela

PY - 2023/1/12

Y1 - 2023/1/12

N2 - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

AB - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

KW - PET imaging

KW - ammonium trifluoroborates

KW - cisplatin

KW - drug delivery

KW - metallacages

KW - self-assembly

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