Peptidoglycan Deacetylases in Bacterial Cell Wall Remodeling and Pathogenesis

Producció científica: Article en revista indexadaArticleAvaluat per experts

5 Cites (Scopus)

Resum

The bacterial cell wall peptidoglycan (PG) is a dynamic structure that is constantly synthesized, re-modeled and degraded during bacterial division and growth. Post-synthetic modifications modulate the action of endogenous autolysis during PG lysis and remodeling for growth and sporulation, but also they are a mechanism used by pathogenic bacteria to evade the host innate immune system. Modifications of the glycan backbone are limited to the C-2 amine and C-6 hydroxyl moieties of either GlcNAc or MurNAc residues. This paper reviews the functional roles and properties of peptidoglycan de-N-acetylases (distinct PG GlcNAc and MurNAc deacetylases) and recent progress through genetic studies and biochemical characterization to elucidate their mechanism of action, 3D structures, substrate specificities and biological functions. Since they are virulence factors in pathogenic bacteria, peptidoglycan deacetylases are potential targets for the design of novel antimicrobial agents.

Idioma originalAnglès
Pàgines (de-a)1293-1312
Nombre de pàgines20
RevistaCurrent Medicinal Chemistry
Volum29
Número7
DOIs
Estat de la publicacióPublicada - de febr. 2022

Fingerprint

Navegar pels temes de recerca de 'Peptidoglycan Deacetylases in Bacterial Cell Wall Remodeling and Pathogenesis'. Junts formen un fingerprint únic.

Com citar-ho