Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig; C. Mestres; J. M.García Antón; G. Valencia; M. A. Alsina

doi:10.1016/0378-5173(88)90126-3

Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig, C. Mestres, J. M.García Antón, G. Valencia, M. A. Alsina

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Resum

The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m^-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m^-1.

Idioma original	Anglès
Pàgines (de-a)	269-272
Nombre de pàgines	4
Revista	International Journal of Pharmaceutics
Volum	44
Número	1-3
DOIs	https://doi.org/10.1016/0378-5173(88)90126-3
Estat de la publicació	Publicada - de juny 1988
Publicat externament	Sí

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10.1016/0378-5173(88)90126-3

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@article{76954160df4840cabedcf006eecfd310,

title = "Penetration of morphine and naloxone in phosphatidylserine monolayers",

abstract = "The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.",

keywords = "Adsorption kinetics, Monolayer, Opiate-phospholipid interaction",

author = "F. Reig and C. Mestres and Ant{\'o}n, {J. M.Garc{\'i}a} and G. Valencia and Alsina, {M. A.}",

year = "1988",

month = jun,

doi = "10.1016/0378-5173(88)90126-3",

language = "English",

volume = "44",

pages = "269--272",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Penetration of morphine and naloxone in phosphatidylserine monolayers

AU - Reig, F.

AU - Mestres, C.

AU - Antón, J. M.García

AU - Valencia, G.

AU - Alsina, M. A.

PY - 1988/6

Y1 - 1988/6

N2 - The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

AB - The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

KW - Adsorption kinetics

KW - Monolayer

KW - Opiate-phospholipid interaction

UR - http://www.scopus.com/inward/record.url?scp=0023946334&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(88)90126-3

DO - 10.1016/0378-5173(88)90126-3

M3 - Article

AN - SCOPUS:0023946334

SN - 0378-5173

VL - 44

SP - 269

EP - 272

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-3

ER -

Penetration of morphine and naloxone in phosphatidylserine monolayers

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