Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes

Borja Cendón, Noelia Casanova, Cezar C. Comanescu, Rebeca García-Fandiño, Andrés Seoane, Moisés Gulías, José L. Mascareñas

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Resum

2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C-H activation of the alkenylanilide involves a classical concerted metalation-deprotonation (CMD) mechanism.

Idioma originalAnglès
Pàgines (de-a)1674-1677
Nombre de pàgines4
RevistaOrganic Letters
Volum19
Número7
DOIs
Estat de la publicacióPublicada - 7 d’abr. 2017
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