On the mechanism of Candida spp. photoinactivation by hypericin

Patricia López-Chicón, Manuel P. Paz-Cristobal, Antonio Rezusta, Carmen Aspiroz, María Royo-Cañas, Elena Andres-Ciriano, Yolanda Gilaberte, Montserrat Agut, Santi Nonell

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The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

Idioma originalAnglès
Pàgines (de-a)1099-1107
Nombre de pàgines9
RevistaPhotochemical and Photobiological Sciences
Estat de la publicacióPublicada - 1 de juny 2012


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