On the mechanism of Candida spp. photoinactivation by hypericin

Patricia López-Chicón; Manuel P. Paz-Cristobal; Antonio Rezusta; Carmen Aspiroz; María Royo-Cañas; Elena Andres-Ciriano; Yolanda Gilaberte; Montserrat Agut; Santi Nonell

doi:10.1039/c2pp25105a

On the mechanism of Candida spp. photoinactivation by hypericin

Patricia López-Chicón, Manuel P. Paz-Cristobal, Antonio Rezusta, Carmen Aspiroz, María Royo-Cañas, Elena Andres-Ciriano, Yolanda Gilaberte, Montserrat Agut, Santi Nonell

IQS School of Engineering

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Resum

The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

Idioma original	Anglès
Pàgines (de-a)	1099-1107
Nombre de pàgines	9
Revista	Photochemical and Photobiological Sciences
Volum	11
Número	6
DOIs	https://doi.org/10.1039/c2pp25105a
Estat de la publicació	Publicada - 1 de juny 2012

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abstract = "The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.",

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T1 - On the mechanism of Candida spp. photoinactivation by hypericin

AU - López-Chicón, Patricia

AU - Paz-Cristobal, Manuel P.

AU - Rezusta, Antonio

AU - Aspiroz, Carmen

AU - Royo-Cañas, María

AU - Andres-Ciriano, Elena

AU - Gilaberte, Yolanda

AU - Agut, Montserrat

AU - Nonell, Santi

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

AB - The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

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On the mechanism of Candida spp. photoinactivation by hypericin

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