TY - JOUR
T1 - Novel Chitosan-Riboflavin Conjugate with Visible Light-Enhanced Antifungal Properties against Penicillium digitatum
AU - Dibona-Villanueva, Luciano
AU - Fuentealba, Denis
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/1/27
Y1 - 2021/1/27
N2 - A novel chemical conjugate between chitosan (CH) and riboflavin (RF) has been synthesized and characterized via Fourier transform infrared, NMR, and other spectroscopic methods. Photophysical and photochemical properties such as absorption spectra, fluorescence emission, fluorescence anisotropy, and singlet oxygen generation were characterized as well. This new biopolymer-based conjugate was designed to have an antifungal effect enhanced through antimicrobial photodynamic therapy. The antifungal effect of this conjugate (CH-RF) was compared with CH and RF against Penicillium digitatum in vitro. The conjugate showed the highest fungal growth inhibition of all systems tested at a dose of 0.5% w/v. This new biopolymer-based compound could be a promising alternative to fungicides used in citrus fruits postharvest.
AB - A novel chemical conjugate between chitosan (CH) and riboflavin (RF) has been synthesized and characterized via Fourier transform infrared, NMR, and other spectroscopic methods. Photophysical and photochemical properties such as absorption spectra, fluorescence emission, fluorescence anisotropy, and singlet oxygen generation were characterized as well. This new biopolymer-based conjugate was designed to have an antifungal effect enhanced through antimicrobial photodynamic therapy. The antifungal effect of this conjugate (CH-RF) was compared with CH and RF against Penicillium digitatum in vitro. The conjugate showed the highest fungal growth inhibition of all systems tested at a dose of 0.5% w/v. This new biopolymer-based compound could be a promising alternative to fungicides used in citrus fruits postharvest.
KW - antifungal
KW - antimicrobial photodynamic therapy
KW - chemical conjugate
KW - chitosan
KW - penicillium digitatum
KW - riboflavin
UR - http://www.scopus.com/inward/record.url?scp=85099795409&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000614065700006&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1021/acs.jafc.0c08154
DO - 10.1021/acs.jafc.0c08154
M3 - Article
C2 - 33438400
AN - SCOPUS:85099795409
SN - 0021-8561
VL - 69
SP - 945
EP - 954
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 3
ER -