Nodal: Master And Commander Of The Dorsal-Ventral And Left-Right Axes In The Sea Urchin Embryo

M. Dolores Molina; Noémie de Crozé; Emmanuel Haillot; Thierry Lepage

doi:10.1016/j.gde.2013.04.010

Nodal: Master And Commander Of The Dorsal-Ventral And Left-Right Axes In The Sea Urchin Embryo

M. Dolores Molina
, Noémie de Crozé
, Emmanuel Haillot
, Thierry Lepage^*

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article de revisió (sistemàtica) › Avaluat per experts

62 Cites (Scopus)

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Recent studies suggest that specification of the dorsal-ventral and left-right axes of the sea urchin embryo relies on Nodal-expressing signalling centres located in the ventral ectoderm and in the archenteron that share striking similarities with vertebrate organising centres. Nodal and its downstream target BMP2/4 pattern all three germ layers along the dorsal-ventral axis, repress neural fates and control morphogenesis of the larva. Moreover, Nodal establishes left-right asymmetry by repressing formation of the adult rudiment and inhibiting germline cells differentiation on the right side, while BMP2/4 promotes expression of mesodermal genes on the left side. These findings provide a framework for future studies and raise new questions regarding the events upstream and downstream of Nodal and BMP signalling during axis formation.

Idioma original	Anglès
Pàgines (de-a)	445-453
Nombre de pàgines	9
Revista	Current Opinion in Genetics and Development
Volum	23
Número	4
DOIs	https://doi.org/10.1016/j.gde.2013.04.010
Estat de la publicació	Publicada - d’ag. 2013
Publicat externament	Sí

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10.1016/j.gde.2013.04.010

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@article{8fe99a141f26472192d07e0779793ee1,

title = "Nodal: Master And Commander Of The Dorsal-Ventral And Left-Right Axes In The Sea Urchin Embryo",

abstract = "Recent studies suggest that specification of the dorsal-ventral and left-right axes of the sea urchin embryo relies on Nodal-expressing signalling centres located in the ventral ectoderm and in the archenteron that share striking similarities with vertebrate organising centres. Nodal and its downstream target BMP2/4 pattern all three germ layers along the dorsal-ventral axis, repress neural fates and control morphogenesis of the larva. Moreover, Nodal establishes left-right asymmetry by repressing formation of the adult rudiment and inhibiting germline cells differentiation on the right side, while BMP2/4 promotes expression of mesodermal genes on the left side. These findings provide a framework for future studies and raise new questions regarding the events upstream and downstream of Nodal and BMP signalling during axis formation.",

keywords = "Oral-aboral axis, Left-right asymmetry, Strongylocentrotus-purpuratus, Regulatory control, Gene-expression, Animal-vegetal, Right side, Specification, Fate, Pathway",

author = "Molina, \{M. Dolores\} and \{de Croz{\'e}\}, No{\'e}mie and Emmanuel Haillot and Thierry Lepage",

year = "2013",

month = aug,

doi = "10.1016/j.gde.2013.04.010",

language = "English",

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pages = "445--453",

journal = "Current Opinion in Genetics and Development",

issn = "0959-437X",

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TY - JOUR

T1 - Nodal

T2 - Master And Commander Of The Dorsal-Ventral And Left-Right Axes In The Sea Urchin Embryo

AU - Molina, M. Dolores

AU - de Crozé, Noémie

AU - Haillot, Emmanuel

AU - Lepage, Thierry

PY - 2013/8

Y1 - 2013/8

N2 - Recent studies suggest that specification of the dorsal-ventral and left-right axes of the sea urchin embryo relies on Nodal-expressing signalling centres located in the ventral ectoderm and in the archenteron that share striking similarities with vertebrate organising centres. Nodal and its downstream target BMP2/4 pattern all three germ layers along the dorsal-ventral axis, repress neural fates and control morphogenesis of the larva. Moreover, Nodal establishes left-right asymmetry by repressing formation of the adult rudiment and inhibiting germline cells differentiation on the right side, while BMP2/4 promotes expression of mesodermal genes on the left side. These findings provide a framework for future studies and raise new questions regarding the events upstream and downstream of Nodal and BMP signalling during axis formation.

AB - Recent studies suggest that specification of the dorsal-ventral and left-right axes of the sea urchin embryo relies on Nodal-expressing signalling centres located in the ventral ectoderm and in the archenteron that share striking similarities with vertebrate organising centres. Nodal and its downstream target BMP2/4 pattern all three germ layers along the dorsal-ventral axis, repress neural fates and control morphogenesis of the larva. Moreover, Nodal establishes left-right asymmetry by repressing formation of the adult rudiment and inhibiting germline cells differentiation on the right side, while BMP2/4 promotes expression of mesodermal genes on the left side. These findings provide a framework for future studies and raise new questions regarding the events upstream and downstream of Nodal and BMP signalling during axis formation.

KW - Oral-aboral axis

KW - Left-right asymmetry

KW - Strongylocentrotus-purpuratus

KW - Regulatory control

KW - Gene-expression

KW - Animal-vegetal

KW - Right side

KW - Specification

KW - Fate

KW - Pathway

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U2 - 10.1016/j.gde.2013.04.010

DO - 10.1016/j.gde.2013.04.010

M3 - Review

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AN - SCOPUS:84883460180

SN - 0959-437X

VL - 23

SP - 445

EP - 453

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 4

ER -

Nodal: Master And Commander Of The Dorsal-Ventral And Left-Right Axes In The Sea Urchin Embryo

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