New variants of the ADEQUATE experiments

Josep Sauri, Ikenna E. Ndukwe, Mikhail Reibarkh, Yizhou Liu, R. Thomas Williamson, Gary E. Martin

Producció científica: Capítol de llibreCapítolAvaluat per experts

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Resum

ADEQUATE experiments were first described in the mid-1990s and are a family of proton-detected NMR experiments used to establish carbon-carbon correlations at natural abundance. Applications of these experiments were initially limited by the statistical probability of two C-13 nuclides in the same molecule (similar to 1:10,000) and the low intrinsic sensitivity of the NMR probe technology of the day. In the intervening two decades, there have been significant advances in NMR probe technology and it is now possible, for example, to perform multiplicity-edited pure shift HSQC NMR experiments on a microgram of material or less. The enhanced NMR sensitivity offered by cryogenic NMR probes has dropped sample requirements for ADEQUATE experiments from the similar to 10mg range to less than a milligram when working with a 1.7mm Micro Cryoprobe (TM) at 600MHz on a modern spectrometer. In parallel with advances in NMR probe technology, this chapter will detail a number of modifications of the ADEQUATE experiment that have been reported to enhance both the utility and sensitivity of these experiments. Combining newly reported variants of the ADEQUATE experiments with anisotropic NMR and Computer-Assisted Structure Elucidation methods affords an orthogonal means of verifying both the constitution and configuration of complex molecular structures that can stem the flow of incorrectly reported structures into the chemical literature.
Idioma originalAnglès
Títol de la publicacióAnnual Reports On Nmr Spectroscopy, Vol 98
EditorsGA Webb
EditorElsevier
Pàgines1-56
Nombre de pàgines56
Volum98
ISBN (electrònic)978-0-08-102910-7
DOIs
Estat de la publicacióPublicada - 2019
Publicat externament

Sèrie de publicacions

NomAnnual Reports On Nmr Spectroscopy

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