NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

Renzo P. Zanocco; Roger Bresolí-Obach; Francisco Nájera; Ezequiel Pérez-Inestrosa; Antonio L. Zanocco; Else Lemp; Santi Nonell

doi:10.3390/s23104603

NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

Renzo P. Zanocco^*, Roger Bresolí-Obach, Francisco Nájera, Ezequiel Pérez-Inestrosa, Antonio L. Zanocco, Else Lemp, Santi Nonell^*

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

4 Cites (Scopus)

Resum

An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

Idioma original	Anglès
Número d’article	4603
Nombre de pàgines	13
Revista	Sensors (Switzerland)
Volum	23
Número	10
DOIs	https://doi.org/10.3390/s23104603
Estat de la publicació	Publicada - 9 de maig 2023

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10.3390/s23104603Llicència: CC BY

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@article{d5f9489df9eb4f0bbe51673b7a53d9f8,

title = "NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging",

abstract = "An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.",

keywords = "fluorescent nanoprobe, multiphoton excitation, singlet oxygen",

author = "Zanocco, \{Renzo P.\} and Roger Bresol{\'i}-Obach and Francisco N{\'a}jera and Ezequiel P{\'e}rez-Inestrosa and Zanocco, \{Antonio L.\} and Else Lemp and Santi Nonell",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = may,

day = "9",

doi = "10.3390/s23104603",

language = "English",

volume = "23",

journal = "Sensors (Switzerland)",

issn = "1424-8220",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

}

TY - JOUR

T1 - NanoFN10

T2 - A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

AU - Zanocco, Renzo P.

AU - Bresolí-Obach, Roger

AU - Nájera, Francisco

AU - Pérez-Inestrosa, Ezequiel

AU - Zanocco, Antonio L.

AU - Lemp, Else

AU - Nonell, Santi

PY - 2023/5/9

Y1 - 2023/5/9

N2 - An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

AB - An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached to the surface of mesoporous silica nanoparticles. In solution, the fluorescence of the nanoprobe increases upon reaction with singlet oxygen both under one- and multiphoton excitation, with fluorescence enhancements up to 180-fold. The nanoprobe can be readily internalized by macrophage cells and is capable of imaging intracellular singlet oxygen under multiphoton excitation.

KW - fluorescent nanoprobe

KW - multiphoton excitation

KW - singlet oxygen

UR - https://www.scopus.com/pages/publications/85160437602

UR - http://hdl.handle.net/20.500.14342/4662

U2 - 10.3390/s23104603

DO - 10.3390/s23104603

M3 - Article

AN - SCOPUS:85160437602

SN - 1424-8220

VL - 23

JO - Sensors (Switzerland)

JF - Sensors (Switzerland)

IS - 10

M1 - 4603

ER -

NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging

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