TY - JOUR
T1 - Nanocarriers for Combination Therapy in Pancreatic Ductal Adenocarcinoma
T2 - A Comprehensive Review
AU - Pontón, Iris
AU - Sánchez-García, David
N1 - Publisher Copyright:
© 2025 by the authors.
PY - 2025/8
Y1 - 2025/8
N2 - Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers worldwide, characterized by late diagnosis, aggressive progression, and poor response to conventional monotherapies. Combination therapies have emerged as a promising approach to overcome multidrug resistance (MDR), enhance efficacy, and target the complex tumor microenvironment (TME). Nanoparticle-based drug delivery systems (DDSs) have gained significant attention for their ability to co-deliver multiple agents with controlled release profiles. This review comprehensively examines nanoparticle-based platforms developed for PDAC combination therapies, focusing on small-molecule drugs. The systems discussed are drawn from studies published between 2005 and 2025.
AB - Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers worldwide, characterized by late diagnosis, aggressive progression, and poor response to conventional monotherapies. Combination therapies have emerged as a promising approach to overcome multidrug resistance (MDR), enhance efficacy, and target the complex tumor microenvironment (TME). Nanoparticle-based drug delivery systems (DDSs) have gained significant attention for their ability to co-deliver multiple agents with controlled release profiles. This review comprehensively examines nanoparticle-based platforms developed for PDAC combination therapies, focusing on small-molecule drugs. The systems discussed are drawn from studies published between 2005 and 2025.
KW - chemotherapy
KW - combination therapy
KW - multi-drug resistance
KW - nanomedicine
KW - nanoparticles
KW - pancreatic cancer
KW - pancreatic ductal adenocarcinoma
KW - stromal therapy
UR - https://www.scopus.com/pages/publications/105013088498
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:001549522400001&DestLinkType=FullRecord&DestApp=WOS_CPL
UR - http://hdl.handle.net/20.500.14342/5511
U2 - 10.3390/nano15151139
DO - 10.3390/nano15151139
M3 - Review
C2 - 40801679
AN - SCOPUS:105013088498
SN - 2079-4991
VL - 15
JO - Nanomaterials
JF - Nanomaterials
IS - 15
M1 - 1139
ER -
