TY - JOUR
T1 - Modulation of plant HMG-CoA reductase by protein phosphatase 2A, positive and negative control at a key node of metabolism
AU - Antolín-Llovera, Meritxell
AU - Leivar, Pablo
AU - Arró, Montserrat
AU - Ferrer, Albert
AU - Boronat, Albert
AU - Campos, Narciso
N1 - Funding Information:
This work was supported by grants of the Spanish Ministerio de Plant HMGR is a key regulatory enzyme of the MVA path-Ciencia e Innovación (BMC2003-03450 and BFU2006-14655 way and is modulated by many diverse endogenous signals and to N.C., BFU2006-00544 and BIO2009-06984 to A.F. and environmental factors, but the mechanisms behind this control BIO2009-09523 to A.B., all of them including FEDER funds), have remained largely unknown. The recent finding of a com-the Spanish Consolider-Ingenio 2010 Program (CSD2007-00036 plex HMGR control by PP2A under particular stress conditions Centre for Research in Agrigenomics) and the Generalitat de opens new perspectives in the research of both HMGR and Catalunya (2009SGR0026). M.A. and P.L. were recipients of fel-PP2A. It will be interesting to analyze whether PP2A is involved lowships, respectively, from the Spanish Ministerio de Educación in the response of HMGR to other environmental challenges Cultura y Deporte and the Comissió Interdepartamental de and to define the role of phytohormone and calcium signals to Recerca i Innovació Tecnològica.
PY - 2011/8
Y1 - 2011/8
N2 - The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.
AB - The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.
KW - HMG-CoA reductase
KW - HMGR
KW - Isoprenoid biosynthesis
KW - Mevalonate pathway
KW - PP2A
KW - Protein phosphatase 2A
KW - Salt stress
UR - http://www.scopus.com/inward/record.url?scp=79961182235&partnerID=8YFLogxK
U2 - 10.4161/psb.6.8.16363
DO - 10.4161/psb.6.8.16363
M3 - Review
AN - SCOPUS:79961182235
SN - 1559-2316
VL - 6
SP - 1127
EP - 1131
JO - Plant Signaling and Behavior
JF - Plant Signaling and Behavior
IS - 8
ER -