Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules

F. Reig, C. Mestres, I. Haro, G. Valencia, J. M.García Antón, M. A. Alsina

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8 Cites (Scopus)


The miscibility of phosphatidylserine, phosphatidylcholine, and cholesterol in monolayers were studied. The influence of sodium and calcium ions in this system was determined. The compression isotherms of mixed monolayers of the above cited three components spread on subphases containing opiate molecules are elucidated. Moreover, the penetration kinetics of opiate molecules in these mixed monolayers was also recorded. The results show that the presence of cholesterol always lowers the penetration of opioid molecules; this effect is weaken for meperidine, the most hydrophobic of the molecules assayed.

Idioma originalAnglès
Pàgines (de-a)139-144
Nombre de pàgines6
RevistaColloid and Polymer Science
Estat de la publicacióPublicada - de febr. 1989
Publicat externament


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