Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules

F. Reig; C. Mestres; I. Haro; G. Valencia; J. M.García Antón; M. A. Alsina

doi:10.1007/BF01410352

Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules

F. Reig, C. Mestres, I. Haro, G. Valencia, J. M.García Antón, M. A. Alsina

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The miscibility of phosphatidylserine, phosphatidylcholine, and cholesterol in monolayers were studied. The influence of sodium and calcium ions in this system was determined. The compression isotherms of mixed monolayers of the above cited three components spread on subphases containing opiate molecules are elucidated. Moreover, the penetration kinetics of opiate molecules in these mixed monolayers was also recorded. The results show that the presence of cholesterol always lowers the penetration of opioid molecules; this effect is weaken for meperidine, the most hydrophobic of the molecules assayed.

Idioma original	Anglès
Pàgines (de-a)	139-144
Nombre de pàgines	6
Revista	Colloid and Polymer Science
Volum	267
Número	2
DOIs	https://doi.org/10.1007/BF01410352
Estat de la publicació	Publicada - de febr. 1989
Publicat externament	Sí

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title = "Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules",

abstract = "The miscibility of phosphatidylserine, phosphatidylcholine, and cholesterol in monolayers were studied. The influence of sodium and calcium ions in this system was determined. The compression isotherms of mixed monolayers of the above cited three components spread on subphases containing opiate molecules are elucidated. Moreover, the penetration kinetics of opiate molecules in these mixed monolayers was also recorded. The results show that the presence of cholesterol always lowers the penetration of opioid molecules; this effect is weaken for meperidine, the most hydrophobic of the molecules assayed.",

keywords = "Opiates, cholesterol, monolayers, penetration kinetics, phosphatidylcholine, phosphatidylserine",

author = "F. Reig and C. Mestres and I. Haro and G. Valencia and Ant{\'o}n, {J. M.Garc{\'i}a} and Alsina, {M. A.}",

year = "1989",

month = feb,

doi = "10.1007/BF01410352",

language = "English",

volume = "267",

pages = "139--144",

journal = "Colloid and Polymer Science",

issn = "0303-402X",

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TY - JOUR

T1 - Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules

AU - Reig, F.

AU - Mestres, C.

AU - Haro, I.

AU - Valencia, G.

AU - Antón, J. M.García

AU - Alsina, M. A.

PY - 1989/2

Y1 - 1989/2

N2 - The miscibility of phosphatidylserine, phosphatidylcholine, and cholesterol in monolayers were studied. The influence of sodium and calcium ions in this system was determined. The compression isotherms of mixed monolayers of the above cited three components spread on subphases containing opiate molecules are elucidated. Moreover, the penetration kinetics of opiate molecules in these mixed monolayers was also recorded. The results show that the presence of cholesterol always lowers the penetration of opioid molecules; this effect is weaken for meperidine, the most hydrophobic of the molecules assayed.

AB - The miscibility of phosphatidylserine, phosphatidylcholine, and cholesterol in monolayers were studied. The influence of sodium and calcium ions in this system was determined. The compression isotherms of mixed monolayers of the above cited three components spread on subphases containing opiate molecules are elucidated. Moreover, the penetration kinetics of opiate molecules in these mixed monolayers was also recorded. The results show that the presence of cholesterol always lowers the penetration of opioid molecules; this effect is weaken for meperidine, the most hydrophobic of the molecules assayed.

KW - Opiates

KW - cholesterol

KW - monolayers

KW - penetration kinetics

KW - phosphatidylcholine

KW - phosphatidylserine

UR - http://www.scopus.com/inward/record.url?scp=0024611652&partnerID=8YFLogxK

U2 - 10.1007/BF01410352

DO - 10.1007/BF01410352

M3 - Article

AN - SCOPUS:0024611652

SN - 0303-402X

VL - 267

SP - 139

EP - 144

JO - Colloid and Polymer Science

JF - Colloid and Polymer Science

IS - 2

ER -

Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules

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