TY - JOUR
T1 - Mediterranean Diet, Energy Restriction, Physical Activity, and Atherogenicity of Very-Low Density Lipoproteins
T2 - Findings from Two Randomized Controlled Trials
AU - Pérez-Vega, Karla Alejandra
AU - Castañer, Olga
AU - Sanllorente, Albert
AU - Lassale, Camille
AU - Ros, Emilio
AU - Pintó, Xavier
AU - Estruch, Ramón
AU - Salas-Salvadó, Jordi
AU - Corella, Dolores
AU - Alonso-Gómez, Ángel M.
AU - Serra-Majem, Lluis
AU - Razquin, Cristina
AU - Fiol, Miquel
AU - Lapetra, José
AU - Gómez-Gracia, Enrique
AU - Tinahones, Francisco J.
AU - Hernáez, Álvaro
AU - Fitó, Montserrat
N1 - Publisher Copyright: © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
PY - 2023/1
Y1 - 2023/1
N2 - Scope: Some very-low density lipoprotein (VLDL) properties may render them more pro-atherogenic. We aimed to assess whether a Mediterranean diet (MedDiet) or an energy-reduced MedDiet with increased physical activity improves them. Methods and results: In a sample of the PREvención con DIeta MEDiterránea (PREDIMED) study, a 1-year intervention with MedDiet with extra-virgin olive oil (n = 89) or nuts (MedDiet-Nuts; n = 79) is compared with a low-fat diet (n = 90). In the PREDIMED-Plus study, a 1-year intervention with energy-reduced MedDiet and physical activity (n = 103) is compared with an ad libitum MedDiet (n = 101). VLDL levels of apolipoprotein C-I, C-III, triglycerides, and cholesterol; the apolipoprotein E-/C-I ratio; and VLDL ex-vivo triglyceride transfer are measured. In PREDIMED participants in both MedDiet groups combined, VLDL apolipoprotein C-III levels are nominally reduced (−0.023 SD units, 95% CI −0.44 to −0.014, p = 0.037). VLDL triglyceride transfer is nominally increased in the MedDiet-Nuts group (+0.39 SD units, 95% CI 0.012–0.78, p = 0.045). In PREDIMED-Plus, no inter-group differences are detected. Conclusions: In older adults at high cardiovascular risk, MedDiet is associated with lower VLDL atherogenicity versus a low-fat diet. No differences are seen after an energy-reduced MedDiet with physical activity.
AB - Scope: Some very-low density lipoprotein (VLDL) properties may render them more pro-atherogenic. We aimed to assess whether a Mediterranean diet (MedDiet) or an energy-reduced MedDiet with increased physical activity improves them. Methods and results: In a sample of the PREvención con DIeta MEDiterránea (PREDIMED) study, a 1-year intervention with MedDiet with extra-virgin olive oil (n = 89) or nuts (MedDiet-Nuts; n = 79) is compared with a low-fat diet (n = 90). In the PREDIMED-Plus study, a 1-year intervention with energy-reduced MedDiet and physical activity (n = 103) is compared with an ad libitum MedDiet (n = 101). VLDL levels of apolipoprotein C-I, C-III, triglycerides, and cholesterol; the apolipoprotein E-/C-I ratio; and VLDL ex-vivo triglyceride transfer are measured. In PREDIMED participants in both MedDiet groups combined, VLDL apolipoprotein C-III levels are nominally reduced (−0.023 SD units, 95% CI −0.44 to −0.014, p = 0.037). VLDL triglyceride transfer is nominally increased in the MedDiet-Nuts group (+0.39 SD units, 95% CI 0.012–0.78, p = 0.045). In PREDIMED-Plus, no inter-group differences are detected. Conclusions: In older adults at high cardiovascular risk, MedDiet is associated with lower VLDL atherogenicity versus a low-fat diet. No differences are seen after an energy-reduced MedDiet with physical activity.
KW - Mediterranean diet
KW - energy-reduced diet
KW - randomized controlled trial
KW - triglycerides
KW - very low-density lipoprotein
UR - http://www.scopus.com/inward/record.url?scp=85143758126&partnerID=8YFLogxK
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000888908700001
U2 - 10.1002/mnfr.202200338
DO - 10.1002/mnfr.202200338
M3 - Article
C2 - 36353918
AN - SCOPUS:85143758126
SN - 1613-4125
VL - 67
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 1
M1 - 2200338
ER -