Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Sabine Rohrmann, Jakob Linseisen, Kim Overvad, Anne Mette Lund Würtz, Nina Roswall, Anne Tjonneland, Marie Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Domenico Palli, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Steffen Weikert, Annika Steffen, Tilman Kühn, Kuanrong Li, Kay Tee Khaw, Nicholas J. WarehamKathryn E. Bradbury, Eleni Peppa, Antonia Trichopoulou, Dimitrios Trichopoulos, H. Bas Bueno-De-Mesquita, Petra H.M. Peeters, Anette Hjartåker, Guri Skeie, Elisabete Weiderpass, Paula Jakszyn, Miren Dorronsoro, Aurelio Barricarte, Carmen Santiuste De Pablos, Esther Molina-Montes, Ramón Alonso De La Torre, Ulrika Ericson, Emily Sonestedt, Mattias Johansson, Börje Ljungberg, Heinz Freisling, Isabelle Romieu, Amanda J. Cross, Anne Claire Vergnaud, Elio Riboli, Heiner Boeing

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Resum

Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear.

Idioma originalAnglès
Pàgines (de-a)E423-E431
RevistaInternational Journal of Cancer
Volum136
Número5
DOIs
Estat de la publicacióPublicada - 1 de març 2015
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