TY - JOUR
T1 - MAMI
T2 - A birth cohort focused on maternal-infant microbiota during early life
AU - García-Mantrana, Izaskun
AU - Alcántara, Cristina
AU - Selma-Royo, Marta
AU - Boix-Amorós, Alba
AU - Dzidic, Majda
AU - Gimeno-Alcañiz, Jose
AU - Úbeda-Sansano, Isabel
AU - Sorribes-Monrabal, Ignacio
AU - Escuriet, Ramón
AU - Gil-Raga, Fernando
AU - Parra-Llorca, Anna
AU - Martínez-Costa, Cecilia
AU - Collado, María Carmen
AU - Baüerl, Christine
AU - Villoldo, Eva
AU - Zafra, Carlos
AU - Olivares, Laura
AU - Pérez-Martínez, Gaspar
AU - Mira, Alex
AU - Ferrer, Maria Desamparados
AU - Martínez Santamaria, Jacobo
AU - Ahicart, Andrea
AU - Vento, Máximo
AU - Gormaz, María
AU - Cernada, María
AU - Bertúa-Ríos, Bibiana
AU - Padilla, Beatriz
AU - Crehuá-Gaudiza, Elena
AU - Peretó-Moll, Alba
AU - Rodríguez García, Amparo
AU - Soler Rico, Maria Dolores
AU - Bixquert Martínez, Nuria
AU - Rausell Segarra, Irene
AU - Tortajada Soriano, Jose Luis
AU - Blesa-Baviera, Luis C.
AU - Peris Vidal, Amelia
AU - Madrigal Hornos, Llanos
AU - Gonzalo Del Moral, Teresa
AU - Domínguez Cano, Pepi
AU - Franch I Ferrer, Marga
AU - Delgado, Concha
AU - Atero, Adela
N1 - Funding Information:
This study is supported through a five-year grant from European Research Council (ERC) - European Union’s Horizon 2020 Framework - with an ERC Starting Grant (ref. 639226). Funding received from this grant supports direct research costs and research assistant salaries. The ERC had no direct role in the design of this study and will not in the collection, analysis or interpreting of data, or manuscript writing.
Publisher Copyright:
© 2019 The Author(s).
PY - 2019/5/3
Y1 - 2019/5/3
N2 - Background: Early microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000 days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization. Methods: MAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24 months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders. MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine. Trial registration: The study is registered on the ClinicalTrial.gov platform NCT03552939. (June 12, 2018).
AB - Background: Early microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000 days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization. Methods: MAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24 months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders. MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine. Trial registration: The study is registered on the ClinicalTrial.gov platform NCT03552939. (June 12, 2018).
KW - Antibiotics
KW - Birth
KW - Breast milk
KW - Cohort study
KW - Diet
KW - Early nutrition
KW - Growth
KW - Lactation
KW - Meconium
KW - Microbiota
KW - Neonates
UR - http://www.scopus.com/inward/record.url?scp=85065231313&partnerID=8YFLogxK
U2 - 10.1186/s12887-019-1502-y
DO - 10.1186/s12887-019-1502-y
M3 - Article
C2 - 31053102
AN - SCOPUS:85065231313
SN - 1471-2431
VL - 19
JO - BMC Pediatrics
JF - BMC Pediatrics
IS - 1
M1 - 140
ER -
