Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

João Conde, Nuria Oliva, Yi Zhang, Natalie Artzi

Producció científica: Article en revista indexadaArticleAvaluat per experts

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Resum

Conventional cancer therapies involve the systemic delivery of anticancer agents that neither discriminate between cancer and normal cells nor eliminate the risk of cancer recurrence. Here, we demonstrate that the combination of gene, drug and phototherapy delivered through a prophylactic hydrogel patch leads, in a colon cancer mouse model, to complete tumour remission when applied to non-resected tumours and to the absence of tumour recurrence when applied following tumour resection. The adhesive hydrogel patch enhanced the stability and provided local delivery of embedded nanoparticles. Spherical gold nanoparticles were used as a first wave of treatment to deliver siRNAs against Kras, a key oncogene driver, and rod-shaped gold nanoparticles mediated the conversion of near-infrared radiation into heat, causing the release of a chemotherapeutic as well as thermally induced cell damage. This local, triple-combination therapy can be adapted to other cancer cell types and to molecular targets associated with disease progression.

Idioma originalAnglès
Pàgines (de-a)1128-1138
Nombre de pàgines11
RevistaNature Materials
Volum15
Número10
DOIs
Estat de la publicacióPublicada - 1 d’oct. 2016
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