Lack of Astrocytic Glycogen Alters Synaptic Plasticity but Not Seizure Susceptibility

Jordi Duran, M. Kathryn Brewer, Arnau Hervera, Agnès Gruart, Jose Antonio del Rio, José M. Delgado-García, Joan J. Guinovart

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Resum

Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons. By conditional deletion of glycogen synthase (GYS1), we previously developed a mouse model entirely devoid of glycogen in the central nervous system (GYS1Nestin-KO). These mice displayed altered electrophysiological properties in the hippocampus and increased susceptibility to kainate-induced seizures. To understand which of these functions are related to astrocytic glycogen, in the present study, we generated a mouse model in which glycogen synthesis is eliminated specifically in astrocytes (GYS1Gfap-KO). Electrophysiological recordings of awake behaving mice revealed alterations in input/output curves and impaired long-term potentiation, similar, but to a lesser extent, to those obtained with GYS1Nestin-KO mice. Surprisingly, GYS1Gfap-KO mice displayed no change in susceptibility to kainate-induced seizures as determined by fEPSP recordings and video monitoring. These results confirm the importance of astrocytic glycogen in synaptic plasticity.

Idioma originalAnglès
Pàgines (de-a)4657-4666
Nombre de pàgines10
RevistaMolecular Neurobiology
Volum57
Número11
DOIs
Estat de la publicacióPublicada - 1 de nov. 2020
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