Kinetics of procalcitonin in pediatric patients on extracorporeal membrane oxygenation

Sara Bobillo, Javier Rodríguez-Fanjul, Anna Solé, Julio Moreno, Mònica Balaguer, Elisabeth Esteban, Francisco José Cambra, Iolanda Jordan

Producció científica: Article en revista indexadaArticleAvaluat per experts

6 Cites (Scopus)

Resum

Objectives: To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in pediatric patients who required extracorporeal membrane oxygenation (ECMO) and to analyze its relationship with morbidity and mortality. Patients and methods: Prospective observational study including pediatric patients who required ECMO. Both PCT and CRP were sequentially drawn before ECMO (P0) and until 72 hours after ECMO. Results: A total of 40 patients were recruited. Two cohorts were established based on the value of the P0 PCT (>10 ng/mL). Comparing the kinetics of PCT and CRP in these cohorts, the described curves were the expected for each clinical situation. The cutoff for P0 PCT to predict multiple organ dysfunction syndrome was 2.55 ng/mL (sensibility 83%, specificity 100%). Both PCT and CRP did not predict risk of neurologic sequelae or mortality in any group. Conclusions: Procalcitonin does not seem to be modified by ECMO and could be a good biomarker of evolution.

Idioma originalAnglès
RevistaBiomarker Insights
Volum13
DOIs
Estat de la publicacióPublicada - 1 de gen. 2018
Publicat externament

Fingerprint

Navegar pels temes de recerca de 'Kinetics of procalcitonin in pediatric patients on extracorporeal membrane oxygenation'. Junts formen un fingerprint únic.

Com citar-ho