Isothiocyanate-functionalized mesoporous silica nanoparticles as building blocks for the design of nanovehicles with optimized drug release profile

Gabriel Martínez-Edo, Maria C. Llinàs, Salvador Borrós, David Sánchez-García

Producció científica: Article en revista indexadaArticleAvaluat per experts

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Resum

A straightforward methodology for the synthesis of isothiocyanate-functionalized mesoporous silica nanoparticles (MSNs) by exposure of aminated MSNs to 1,1-thiocarbonyldi-2(1H)-pyridone is reported. These nanoparticles are chemically stable, water tolerant, and readily react with primary amines without the formation of any by-product. This feature allows the easy modification of the surface of the nanoparticles for tuning their physical properties and the introduction of gatekeepers on the pore outlets. As a proof-of-concept, amino-isothiocyanate-functionalized MSNs have been used for the design of a nanocontainer able to release the drug Ataluren. The release profile of the drug can be easily fine-tuned with the careful choice of the capping amine.

Idioma originalAnglès
Número d’article1219
RevistaNanomaterials
Volum9
Número9
DOIs
Estat de la publicacióPublicada - de set. 2019

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