Interaction of opioid molecules with PS, PC and PS/PC monolayers

M. A. Alsina, C. Mestres, G. Valencia, J. M.García Antón, F. Reig

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The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

Idioma originalAnglès
Pàgines (de-a)832-835
Nombre de pàgines4
RevistaColloid and Polymer Science
Estat de la publicacióPublicada - de set. 1988
Publicat externament


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