Interaction of opioid molecules with PS, PC and PS/PC monolayers

M. A. Alsina; C. Mestres; G. Valencia; J. M.García Antón; F. Reig

doi:10.1007/BF01417867

Interaction of opioid molecules with PS, PC and PS/PC monolayers

M. A. Alsina, C. Mestres, G. Valencia, J. M.García Antón, F. Reig

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Resum

The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

Idioma original	Anglès
Pàgines (de-a)	832-835
Nombre de pàgines	4
Revista	Colloid and Polymer Science
Volum	266
Número	9
DOIs	https://doi.org/10.1007/BF01417867
Estat de la publicació	Publicada - de set. 1988
Publicat externament	Sí

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title = "Interaction of opioid molecules with PS, PC and PS/PC monolayers",

abstract = "The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.",

keywords = "Opiates, monolayers, penetration kinetics, phosphatidylcholine, phosphatidylserine",

author = "Alsina, {M. A.} and C. Mestres and G. Valencia and Ant{\'o}n, {J. M.Garc{\'i}a} and F. Reig",

year = "1988",

month = sep,

doi = "10.1007/BF01417867",

language = "English",

volume = "266",

pages = "832--835",

journal = "Colloid and Polymer Science",

issn = "0303-402X",

publisher = "Springer Verlag",

number = "9",

}

TY - JOUR

T1 - Interaction of opioid molecules with PS, PC and PS/PC monolayers

AU - Alsina, M. A.

AU - Mestres, C.

AU - Valencia, G.

AU - Antón, J. M.García

AU - Reig, F.

PY - 1988/9

Y1 - 1988/9

N2 - The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

AB - The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

KW - Opiates

KW - monolayers

KW - penetration kinetics

KW - phosphatidylcholine

KW - phosphatidylserine

UR - http://www.scopus.com/inward/record.url?scp=0024068938&partnerID=8YFLogxK

U2 - 10.1007/BF01417867

DO - 10.1007/BF01417867

M3 - Article

AN - SCOPUS:0024068938

SN - 0303-402X

VL - 266

SP - 832

EP - 835

JO - Colloid and Polymer Science

JF - Colloid and Polymer Science

IS - 9

ER -

Interaction of opioid molecules with PS, PC and PS/PC monolayers

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