TY - JOUR
T1 - Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract
T2 - The prospective EPIC-study
AU - Boeing, Heiner
AU - Dietrich, Thomas
AU - Hoffmann, Kurt
AU - Pischon, Tobias
AU - Ferrari, Pietro
AU - Lahmann, Petra H.
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Francoise
AU - Allen, Naomi
AU - Key, Tim
AU - Skeie, Guri
AU - Lund, Eiliv
AU - Olsen, Anja
AU - Tjonneland, Anne
AU - Overvad, Kim
AU - Jensen, Majken K.
AU - Rohrmann, Sabine
AU - Linseisen, Jakob
AU - Trichopoulou, Antonia
AU - Bamia, Christina
AU - Psaltopoulou, Theodora
AU - Weinehall, Lars
AU - Johansson, Ingegerd
AU - Sánchez, Maria José
AU - Jakszyn, Paula
AU - Ardanaz, Eva
AU - Amiano, Pilar
AU - Chirlaque, Maria Dolores
AU - Quirós, J. Ramón
AU - Wirfalt, Elisabet
AU - Berglund, Göran
AU - Peeters, Petra H.
AU - Van Gils, Carla H.
AU - Bueno-De-Mesquita, H. Bas
AU - Büchner, Frederike L.
AU - Berrino, Franco
AU - Palli, Domenico
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Slimani, Nadia
AU - Norat, Teresa
AU - Jenab, Mazda
AU - Riboli, Elio
N1 - Funding Information:
Acknowledgments We would like to thank all participants for their contribution to this study. Important technical statistical support to this study was given by Wolfgang Bernigau. EPIC is financially supported by: Europe Against Cancer Program of the European Commission (SANCO); Deutsche Krebshilfe; Deuts-ches Krebsforschungszentrum; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; Spanish Regional Governments of Andalucia, Asturia, Basque Country, Murcia and Navarra; ISCIII, red de centros RCESP, C03/09, Spain; Cancer Research UK; Medical Research Council, United Kingdom; Stroke Association, United Kingdom; British Heart Foundation; Department of Health, United Kingdom; Food Standards Agency, United Kingdom; Welcome Trust, United Kingdom; Greek Ministry of Health; Greek Ministry of Education; Italian Association for Research on Cancer (AIRC); Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; National Cancer Registry and the Regional Cancer Registries Amsterdam, Utrecht, East and Maastricht of The Netherlands; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden
PY - 2006/9
Y1 - 2006/9
N2 - Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (<120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.
AB - Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (<120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.
KW - EPIC
KW - Fruits and vegetables
KW - Prospective study
KW - Relative risk
KW - Root vegetables
KW - Upper aero-digestive cancer
UR - http://www.scopus.com/inward/record.url?scp=33746042158&partnerID=8YFLogxK
U2 - 10.1007/s10552-006-0036-4
DO - 10.1007/s10552-006-0036-4
M3 - Article
C2 - 16841263
AN - SCOPUS:33746042158
SN - 0957-5243
VL - 17
SP - 957
EP - 969
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 7
ER -