TY - JOUR
T1 - Initiated chemical vapor deposition of a surface-modifiable copolymer for covalent attachment and patterning of nucleophilic ligands
AU - O'Shaughnessy, W. Shannan
AU - Marí-Buyé, Núria
AU - Borrós, Salvador
AU - Gleason, Karen K.
PY - 2007/9/18
Y1 - 2007/9/18
N2 - Many novel areas of biological investigation require the patterned immobilization of bioactive ligands. In this work, easily modified thin films of poly[(pentafluorophenyl methacrylate) (PFM)-co-(ethylene glycol diacrylate) (EGDA)]are synthesized by initiated chemical vapor deposition (iCVD). PFM possesses a pentafluorophenyl ester side chain moiety, which is an excellent leaving group for the attachment of nucleophilic ligands by a single reaction step, while the EGDA functions as a crosslinking agent. Patterned surface modification through microcontact printing of fluorescently labeled amines that remain immobilized after repeated solvent rinses is demonstrated. Bulk modification of the copolymer with aminoethoxyethanol, which results in a ≈20° reduction in the observed contact angle with water, is also shown.
AB - Many novel areas of biological investigation require the patterned immobilization of bioactive ligands. In this work, easily modified thin films of poly[(pentafluorophenyl methacrylate) (PFM)-co-(ethylene glycol diacrylate) (EGDA)]are synthesized by initiated chemical vapor deposition (iCVD). PFM possesses a pentafluorophenyl ester side chain moiety, which is an excellent leaving group for the attachment of nucleophilic ligands by a single reaction step, while the EGDA functions as a crosslinking agent. Patterned surface modification through microcontact printing of fluorescently labeled amines that remain immobilized after repeated solvent rinses is demonstrated. Bulk modification of the copolymer with aminoethoxyethanol, which results in a ≈20° reduction in the observed contact angle with water, is also shown.
KW - Biomaterials
KW - Ligand patterning
KW - Radical polymerization
KW - iCVD
UR - http://www.scopus.com/inward/record.url?scp=34848887726&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000249899400003&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1002/marc.200700333
DO - 10.1002/marc.200700333
M3 - Article
AN - SCOPUS:34848887726
SN - 1022-1336
VL - 28
SP - 1877
EP - 1882
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
IS - 18-19
ER -