Inhaled drugs as risk factors for communityacquired pneumonia

J. Almirall; I. Bolíbar; M. Serra-Prat; E. Palomera; J. Roig; I. Hospital; E. Carandelle; M. Agustí; P. Ayuso; A. Estela; A. Torres; J. M. De Salas; J. Costa; M. Tristany; M. J. Grau; S. Sancho; E. Miguel; M. Fradera; I. Ochoa; M. J. Castany; A. Quilez; V. Marina; P. Subias; B. Jimeno; Bradnovich; M. Rodriguez; E. Ramon; A. Gardella; C. Ginés; J. C. Montero; P. Flores; P. Serra; E. Torrellas; C. Serrano; M. Pubill; J. Gost; I. Buxadé; J. Mussoll; X. Mestres; A. Armada; J. Mallafré; M. Roger; M. T. Gros; N. Les; J. Joanola; J. Doménech; M. Bundó; M. Trilla; J. Massons; J. Montero; E. Zurilla; M. Alegre; M. Papiol; O. Martí; M. Catalá; M. A. Martinez; A. Casanovas; I. Beisani; C. Tria; E. Diaz; P. Torán; M. M. Aizpurua; G. Lozano; J. Casals; J. Sorribes; D. Torrellas; A. Casas; J. Bernad; A. De Montoliu; J. Gaya; R. Vallés; A. Vazquez; R. Peiró; G. Aresté; G. N. Mengual; M. C. Viñes; E. Almerich; M. A. Lopez; J. Bel; A. Gosalves; S. Macip; E. Carrillo; P. Paulo; M. Pol; J. Sala; P. Mir; J. L.L. Anglada; J. Salabarnada; E. Sanz; F. Gorgas; A. Ribas; E. Fau; I. Pellicer; S. Morales; E. Burdoy; M. Bartolomé; E. Corona; L. Mateu; M. Paret; Y. Verde; A. Borrás; F. Aznar; F. Riera; A. Vazquez; P. Gil; I. Colom; E. Calvet; J. Nicolás; J. Ruiz; P. Carrera; I. Legazpi; F. Planellas; A. Beltran; T. Planas; J. Rovira; M. De Ciurana; C. Xargay; R. B. Cortés; J. Paredes; J. G. Olive; P. Montoya; J. A. El Hosn-Makarem; F. Pelaez; A. Ubieto; F. X. Burcet; D. Alcantarilla; J. De Ribot; M. R. Gorgot; R. A. Bas; M. B. Rosa; J. Castells; J. A. Castillo; J. M. Benet; J. C. Caballero; J. Llach; J. Sanglas; V. Moral; M. Navarro; J. C. Torrent; D. Rodríguez; X. Rius; J. Solanella; A. Fallada; J. I. Cardona; J. Ferrer; A. Josa; M. J. Solís; F. Güerri; J. Boj; C. Ramon; R. Caballol; L. Navarro; J. Masqué; M. J. Murillo; M. D. Llovet; I. Guinea; M. M. Juárez; M. Alvarez; J. Bladé; I. Sánchez Oró; F. Martin; J. J. Cabré; J. Frigola; J. Requena; E. Favà; M. J. Pinazo; M. Ros; S. Borrás; J. Sala; C. Nolla; J. Bitrià; O. Araujo; M. Alonso; T. Glaria; A. Chacon; E. Satué; A. Collado; Ll Llor; D. Montanyés; G. Garcia; M. J. Arasa; A. Yoldi; I. Viloria; F. Vallespi; J. L.L. Clua; J. M. Basart; E. Ciurana; J. F. Monclus; A. Casanovas; L. Viñas; E. Checa; J. Marin; J. Santigosa; T. Basora; F. Gallego; E. Martin; P. Gil; M. Roselló; I. Arayo; F. Palacios; A. Donado; J. Marimon; B. Costa; C. Gutiérrez; E. Moltó; A. Isach; N. Izzeddin; M. Campani; J. Ferré; A. Fernández; J. Jové; J. Vilalta; E. Ribera; M. Fernández; O. Ochoa; A. Vila; J. Pujol; M. A. Navarro; C. Campillos; A. Juarez; J. Perez; I. Casado; E. Paredes; J. Rodriguez; A. Vazquez; Y. Solà; J. Berdié; M. J. Andrés; B. Barragan; A. Torras; M. Madrid; S. Gonzalez; A. Fuentes; M. Iñiguez; J. Guasch; F. Sánchez; J. Pascual; A. Castelló; Ll Gómez; C. Mateu; J. Arranz; A. Fé; B. Puig; M. Gutiérrez; Ll Morant; M. Llull; J. Estelrich; L. Quintana; C. Llabrés; M. M. Sureda; L. Cuevas; Y. Muñoz; J. Llobera; P. Marin; C. Garcia; P. Moreno; M. Coll; C. Palma; C. Ribera; J. Aldosa; C. Alonso; A. Bergés; J. Burgués; Ll Burgués; J. Busquets; D. Casal; N. Cerdán; X. Crespo; R. Duat; J. Escoda; M. Fiter; A. Font; M. Fraysse; S. Fuentes; R. García-Núñez; T. López-Pinacho; M. Masardo; J. Martínez-Illescas; P. Morisset; M. Pallarés; R. Pérez-Serra; A. Plà; E. Pons; A. Ruiz; J. C. Rodríguez-Picart; J. Sánchez-Claver; E. Sylvestre; R. Tolosa; J. A. Touceda; J. R. Varela; J. C. Vidal; M. Amate; C. Bara; O. Becerra; R. Bellmunt; F. Boneu; J. Bozal; C. Burillo; A. Díaz; N. González; A. Granyena; M. Gutiérrez; C. Infante; M. Leal; M. Linares; J. Magallón; J. Marqués; M. J. Martí; J. C. Miralles; C. Mora; J. M. Palacín; J. Pons; G. Prats; G. Pujal; M. Sanjuán; X. Segarra; J. Solís; H. Trelles; G. De Celis; X. Latorre; O. Sarroca; H. Briceño

doi:10.1183/09031936.00022909

Inhaled drugs as risk factors for communityacquired pneumonia

J. Almirall^*, I. Bolíbar, M. Serra-Prat, E. Palomera, J. Roig, I. Hospital, E. Carandelle, M. Agustí, P. Ayuso, A. Estela, A. Torres, J. M. De Salas, J. Costa, M. Tristany, M. J. Grau, S. Sancho, E. Miguel, M. Fradera, I. Ochoa, M. J. CastanyA. Quilez, V. Marina, P. Subias, B. Jimeno, Bradnovich, M. Rodriguez, E. Ramon, A. Gardella, C. Ginés, J. C. Montero, P. Flores, P. Serra, E. Torrellas, C. Serrano, M. Pubill, J. Gost, I. Buxadé, J. Mussoll, X. Mestres, A. Armada, J. Mallafré, M. Roger, M. T. Gros, N. Les, J. Joanola, J. Doménech, M. Bundó, M. Trilla, J. Massons, J. Montero, E. Zurilla, M. Alegre, M. Papiol, O. Martí, M. Catalá, M. A. Martinez, A. Casanovas, I. Beisani, C. Tria, E. Diaz, P. Torán, M. M. Aizpurua, G. Lozano, J. Casals, J. Sorribes, D. Torrellas, A. Casas, J. Bernad, A. De Montoliu, J. Gaya, R. Vallés, A. Vazquez, R. Peiró, G. Aresté, G. N. Mengual, M. C. Viñes, E. Almerich, M. A. Lopez, J. Bel, A. Gosalves, S. Macip, E. Carrillo, P. Paulo, M. Pol, J. Sala, P. Mir, J. L.L. Anglada, J. Salabarnada, E. Sanz, F. Gorgas, A. Ribas, E. Fau, I. Pellicer, S. Morales, E. Burdoy, M. Bartolomé, E. Corona, L. Mateu, M. Paret, Y. Verde, A. Borrás, F. Aznar, F. Riera, A. Vazquez, P. Gil, I. Colom, E. Calvet, J. Nicolás, J. Ruiz, P. Carrera, I. Legazpi, F. Planellas, A. Beltran, T. Planas, J. Rovira, M. De Ciurana, C. Xargay, R. B. Cortés, J. Paredes, J. G. Olive, P. Montoya, J. A. El Hosn-Makarem, F. Pelaez, A. Ubieto, F. X. Burcet, D. Alcantarilla, J. De Ribot, M. R. Gorgot, R. A. Bas, M. B. Rosa, J. Castells, J. A. Castillo, J. M. Benet, J. C. Caballero, J. Llach, J. Sanglas, V. Moral, M. Navarro, J. C. Torrent, D. Rodríguez, X. Rius, J. Solanella, A. Fallada, J. I. Cardona, J. Ferrer, A. Josa, M. J. Solís, F. Güerri, J. Boj, C. Ramon, R. Caballol, L. Navarro, J. Masqué, M. J. Murillo, M. D. Llovet, I. Guinea, M. M. Juárez, M. Alvarez, J. Bladé, I. Sánchez Oró, F. Martin, J. J. Cabré, J. Frigola, J. Requena, E. Favà, M. J. Pinazo, M. Ros, S. Borrás, J. Sala, C. Nolla, J. Bitrià, O. Araujo, M. Alonso, T. Glaria, A. Chacon, E. Satué, A. Collado, Ll Llor, D. Montanyés, G. Garcia, M. J. Arasa, A. Yoldi, I. Viloria, F. Vallespi, J. L.L. Clua, J. M. Basart, E. Ciurana, J. F. Monclus, A. Casanovas, L. Viñas, E. Checa, J. Marin, J. Santigosa, T. Basora, F. Gallego, E. Martin, P. Gil, M. Roselló, I. Arayo, F. Palacios, A. Donado, J. Marimon, B. Costa, C. Gutiérrez, E. Moltó, A. Isach, N. Izzeddin, M. Campani, J. Ferré, A. Fernández, J. Jové, J. Vilalta, E. Ribera, M. Fernández, O. Ochoa, A. Vila, J. Pujol, M. A. Navarro, C. Campillos, A. Juarez, J. Perez, I. Casado, E. Paredes, J. Rodriguez, A. Vazquez, Y. Solà, J. Berdié, M. J. Andrés, B. Barragan, A. Torras, M. Madrid, S. Gonzalez, A. Fuentes, M. Iñiguez, J. Guasch, F. Sánchez, J. Pascual, A. Castelló, Ll Gómez, C. Mateu, J. Arranz, A. Fé, B. Puig, M. Gutiérrez, Ll Morant, M. Llull, J. Estelrich, L. Quintana, C. Llabrés, M. M. Sureda, L. Cuevas, Y. Muñoz, J. Llobera, P. Marin, C. Garcia, P. Moreno, M. Coll, C. Palma, C. Ribera, J. Aldosa, C. Alonso, A. Bergés, J. Burgués, Ll Burgués, J. Busquets, D. Casal, N. Cerdán, X. Crespo, R. Duat, J. Escoda, M. Fiter, A. Font, M. Fraysse, S. Fuentes, R. García-Núñez, T. López-Pinacho, M. Masardo, J. Martínez-Illescas, P. Morisset, M. Pallarés, R. Pérez-Serra, A. Plà, E. Pons, A. Ruiz, J. C. Rodríguez-Picart, J. Sánchez-Claver, E. Sylvestre, R. Tolosa, J. A. Touceda, J. R. Varela, J. C. Vidal, M. Amate, C. Bara, O. Becerra, R. Bellmunt, F. Boneu, J. Bozal, C. Burillo, A. Díaz, N. González, A. Granyena, M. Gutiérrez, C. Infante, M. Leal, M. Linares, J. Magallón, J. Marqués, M. J. Martí, J. C. Miralles, C. Mora, J. M. Palacín, J. Pons, G. Prats, G. Pujal, M. Sanjuán, X. Segarra, J. Solís, H. Trelles, G. De Celis, X. Latorre, O. Sarroca, H. Briceño

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

33 Cites (Scopus)

Resum

The effect of inhaled drugs in community-acquired pneumonia (CAP) is unclear. This case-control study was designed to determine whether inhaled drugs were risk factors for CAP. All incident cases of confirmed CAP that occurred over 1 yr in patients with chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD) or asthma were included, as well as CB, COPD and asthma controls. Risk factors for CAP and inhaled treatment were recorded during a personal interview. An effect of inhaled drugs on the risk of CAP was observed in COPD and asthma patients after adjusting for the effect of other respiratory diseases and their concomitant treatments. In COPD patients, inhaled steroids had a risk OR of 3.26 (95% CI 1.07-9.98) and in asthma patients inhaled anticholinergics had a risk OR of 8.80 (95% CI 1.02-75.7). In CB patients, no association with CAP was observed for any inhaler. These effects were independent of adjusting variables related to severity and other respiratory and non-respiratory risk factors for CAP, including vaccines. Inhaled β₂-adrenergic agonists did not show a significant effect on the risk of CAP in any of the respiratory diseases. Inhaled steroids may favour CAP in COPD patients, whereas anticholinergics may favour CAP in asthma patients. It is difficult to differentiate the effect of inhaled therapy from the effect of COPD or asthma severity on the risk of CAP, and these relationships may not be causal, but could call attention to inhaled therapy in COPD and asthma patients. Copyright

Idioma original	Anglès
Pàgines (de-a)	1080-1087
Nombre de pàgines	8
Revista	European Respiratory Journal
Volum	36
Número	5
DOIs	https://doi.org/10.1183/09031936.00022909
Estat de la publicació	Publicada - 1 de nov. 2010
Publicat externament	Sí

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

Accés al document

10.1183/09031936.00022909

Altres arxius i enllaços

Link to publication in Scopus

Com citar-ho

Almirall, J., Bolíbar, I., Serra-Prat, M., Palomera, E., Roig, J., Hospital, I., Carandelle, E., Agustí, M., Ayuso, P., Estela, A., Torres, A., De Salas, J. M., Costa, J., Tristany, M., Grau, M. J., Sancho, S., Miguel, E., Fradera, M., Ochoa, I., ... Briceño, H. (2010). Inhaled drugs as risk factors for communityacquired pneumonia. European Respiratory Journal, 36(5), 1080-1087. https://doi.org/10.1183/09031936.00022909

@article{819bbd0c435d49c09ede6165bc01defb,

title = "Inhaled drugs as risk factors for communityacquired pneumonia",

abstract = "The effect of inhaled drugs in community-acquired pneumonia (CAP) is unclear. This case-control study was designed to determine whether inhaled drugs were risk factors for CAP. All incident cases of confirmed CAP that occurred over 1 yr in patients with chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD) or asthma were included, as well as CB, COPD and asthma controls. Risk factors for CAP and inhaled treatment were recorded during a personal interview. An effect of inhaled drugs on the risk of CAP was observed in COPD and asthma patients after adjusting for the effect of other respiratory diseases and their concomitant treatments. In COPD patients, inhaled steroids had a risk OR of 3.26 (95% CI 1.07-9.98) and in asthma patients inhaled anticholinergics had a risk OR of 8.80 (95% CI 1.02-75.7). In CB patients, no association with CAP was observed for any inhaler. These effects were independent of adjusting variables related to severity and other respiratory and non-respiratory risk factors for CAP, including vaccines. Inhaled β2-adrenergic agonists did not show a significant effect on the risk of CAP in any of the respiratory diseases. Inhaled steroids may favour CAP in COPD patients, whereas anticholinergics may favour CAP in asthma patients. It is difficult to differentiate the effect of inhaled therapy from the effect of COPD or asthma severity on the risk of CAP, and these relationships may not be causal, but could call attention to inhaled therapy in COPD and asthma patients. Copyright",

keywords = "Community-acquired pneumonia, Inhaled drug treatment, Risk factors",

author = "J. Almirall and I. Bol{\'i}bar and M. Serra-Prat and E. Palomera and J. Roig and I. Hospital and E. Carandelle and M. Agust{\'i} and P. Ayuso and A. Estela and A. Torres and {De Salas}, {J. M.} and J. Costa and M. Tristany and Grau, {M. J.} and S. Sancho and E. Miguel and M. Fradera and I. Ochoa and Castany, {M. J.} and A. Quilez and V. Marina and P. Subias and B. Jimeno and Bradnovich and M. Rodriguez and E. Ramon and A. Gardella and C. Gin{\'e}s and Montero, {J. C.} and P. Flores and P. Serra and E. Torrellas and C. Serrano and M. Pubill and J. Gost and I. Buxad{\'e} and J. Mussoll and X. Mestres and A. Armada and J. Mallafr{\'e} and M. Roger and Gros, {M. T.} and N. Les and J. Joanola and J. Dom{\'e}nech and M. Bund{\'o} and M. Trilla and J. Massons and J. Montero and E. Zurilla and M. Alegre and M. Papiol and O. Mart{\'i} and M. Catal{\'a} and Martinez, {M. A.} and A. Casanovas and I. Beisani and C. Tria and E. Diaz and P. Tor{\'a}n and Aizpurua, {M. M.} and G. Lozano and J. Casals and J. Sorribes and D. Torrellas and A. Casas and J. Bernad and {De Montoliu}, A. and J. Gaya and R. Vall{\'e}s and A. Vazquez and R. Peir{\'o} and G. Arest{\'e} and Mengual, {G. N.} and Vi{\~n}es, {M. C.} and E. Almerich and Lopez, {M. A.} and J. Bel and A. Gosalves and S. Macip and E. Carrillo and P. Paulo and M. Pol and J. Sala and P. Mir and Anglada, {J. L.L.} and J. Salabarnada and E. Sanz and F. Gorgas and A. Ribas and E. Fau and I. Pellicer and S. Morales and E. Burdoy and M. Bartolom{\'e} and E. Corona and L. Mateu and M. Paret and Y. Verde and A. Borr{\'a}s and F. Aznar and F. Riera and A. Vazquez and P. Gil and I. Colom and E. Calvet and J. Nicol{\'a}s and J. Ruiz and P. Carrera and I. Legazpi and F. Planellas and A. Beltran and T. Planas and J. Rovira and {De Ciurana}, M. and C. Xargay and Cort{\'e}s, {R. B.} and J. Paredes and Olive, {J. G.} and P. Montoya and {El Hosn-Makarem}, {J. A.} and F. Pelaez and A. Ubieto and Burcet, {F. X.} and D. Alcantarilla and {De Ribot}, J. and Gorgot, {M. R.} and Bas, {R. A.} and Rosa, {M. B.} and J. Castells and Castillo, {J. A.} and Benet, {J. M.} and Caballero, {J. C.} and J. Llach and J. Sanglas and V. Moral and M. Navarro and Torrent, {J. C.} and D. Rodr{\'i}guez and X. Rius and J. Solanella and A. Fallada and Cardona, {J. I.} and J. Ferrer and A. Josa and Sol{\'i}s, {M. J.} and F. G{\"u}erri and J. Boj and C. Ramon and R. Caballol and L. Navarro and J. Masqu{\'e} and Murillo, {M. J.} and Llovet, {M. D.} and I. Guinea and Ju{\'a}rez, {M. M.} and M. Alvarez and J. Blad{\'e} and {S{\'a}nchez Or{\'o}}, I. and F. Martin and Cabr{\'e}, {J. J.} and J. Frigola and J. Requena and E. Fav{\`a} and Pinazo, {M. J.} and M. Ros and S. Borr{\'a}s and J. Sala and C. Nolla and J. Bitri{\`a} and O. Araujo and M. Alonso and T. Glaria and A. Chacon and E. Satu{\'e} and A. Collado and Ll Llor and D. Montany{\'e}s and G. Garcia and Arasa, {M. J.} and A. Yoldi and I. Viloria and F. Vallespi and Clua, {J. L.L.} and Basart, {J. M.} and E. Ciurana and Monclus, {J. F.} and A. Casanovas and L. Vi{\~n}as and E. Checa and J. Marin and J. Santigosa and T. Basora and F. Gallego and E. Martin and P. Gil and M. Rosell{\'o} and I. Arayo and F. Palacios and A. Donado and J. Marimon and B. Costa and C. Guti{\'e}rrez and E. Molt{\'o} and A. Isach and N. Izzeddin and M. Campani and J. Ferr{\'e} and A. Fern{\'a}ndez and J. Jov{\'e} and J. Vilalta and E. Ribera and M. Fern{\'a}ndez and O. Ochoa and A. Vila and J. Pujol and Navarro, {M. A.} and C. Campillos and A. Juarez and J. Perez and I. Casado and E. Paredes and J. Rodriguez and A. Vazquez and Y. Sol{\`a} and J. Berdi{\'e} and Andr{\'e}s, {M. J.} and B. Barragan and A. Torras and M. Madrid and S. Gonzalez and A. Fuentes and M. I{\~n}iguez and J. Guasch and F. S{\'a}nchez and J. Pascual and A. Castell{\'o} and Ll G{\'o}mez and C. Mateu and J. Arranz and A. F{\'e} and B. Puig and M. Guti{\'e}rrez and Ll Morant and M. Llull and J. Estelrich and L. Quintana and C. Llabr{\'e}s and Sureda, {M. M.} and L. Cuevas and Y. Mu{\~n}oz and J. Llobera and P. Marin and C. Garcia and P. Moreno and M. Coll and C. Palma and C. Ribera and J. Aldosa and C. Alonso and A. Berg{\'e}s and J. Burgu{\'e}s and Ll Burgu{\'e}s and J. Busquets and D. Casal and N. Cerd{\'a}n and X. Crespo and R. Duat and J. Escoda and M. Fiter and A. Font and M. Fraysse and S. Fuentes and R. Garc{\'i}a-N{\'u}{\~n}ez and T. L{\'o}pez-Pinacho and M. Masardo and J. Mart{\'i}nez-Illescas and P. Morisset and M. Pallar{\'e}s and R. P{\'e}rez-Serra and A. Pl{\`a} and E. Pons and A. Ruiz and Rodr{\'i}guez-Picart, {J. C.} and J. S{\'a}nchez-Claver and E. Sylvestre and R. Tolosa and Touceda, {J. A.} and Varela, {J. R.} and Vidal, {J. C.} and M. Amate and C. Bara and O. Becerra and R. Bellmunt and F. Boneu and J. Bozal and C. Burillo and A. D{\'i}az and N. Gonz{\'a}lez and A. Granyena and M. Guti{\'e}rrez and C. Infante and M. Leal and M. Linares and J. Magall{\'o}n and J. Marqu{\'e}s and Mart{\'i}, {M. J.} and Miralles, {J. C.} and C. Mora and Palac{\'i}n, {J. M.} and J. Pons and G. Prats and G. Pujal and M. Sanju{\'a}n and X. Segarra and J. Sol{\'i}s and H. Trelles and {De Celis}, G. and X. Latorre and O. Sarroca and H. Brice{\~n}o",

year = "2010",

month = nov,

day = "1",

doi = "10.1183/09031936.00022909",

language = "English",

volume = "36",

pages = "1080--1087",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "5",

}

Almirall, J, Bolíbar, I, Serra-Prat, M, Palomera, E, Roig, J, Hospital, I, Carandelle, E, Agustí, M, Ayuso, P, Estela, A, Torres, A, De Salas, JM, Costa, J, Tristany, M, Grau, MJ, Sancho, S, Miguel, E, Fradera, M, Ochoa, I, Castany, MJ, Quilez, A, Marina, V, Subias, P, Jimeno, B, Bradnovich, Rodriguez, M, Ramon, E, Gardella, A, Ginés, C, Montero, JC, Flores, P, Serra, P, Torrellas, E, Serrano, C, Pubill, M, Gost, J, Buxadé, I, Mussoll, J, Mestres, X, Armada, A, Mallafré, J, Roger, M, Gros, MT, Les, N, Joanola, J, Doménech, J, Bundó, M, Trilla, M, Massons, J, Montero, J, Zurilla, E, Alegre, M, Papiol, M, Martí, O, Catalá, M, Martinez, MA, Casanovas, A, Beisani, I, Tria, C, Diaz, E, Torán, P, Aizpurua, MM, Lozano, G, Casals, J, Sorribes, J, Torrellas, D, Casas, A, Bernad, J, De Montoliu, A, Gaya, J, Vallés, R, Vazquez, A, Peiró, R, Aresté, G, Mengual, GN, Viñes, MC, Almerich, E, Lopez, MA, Bel, J, Gosalves, A, Macip, S, Carrillo, E, Paulo, P, Pol, M, Sala, J, Mir, P, Anglada, JLL, Salabarnada, J, Sanz, E, Gorgas, F, Ribas, A, Fau, E, Pellicer, I, Morales, S, Burdoy, E, Bartolomé, M, Corona, E, Mateu, L, Paret, M, Verde, Y, Borrás, A, Aznar, F, Riera, F, Vazquez, A, Gil, P, Colom, I, Calvet, E, Nicolás, J, Ruiz, J, Carrera, P, Legazpi, I, Planellas, F, Beltran, A, Planas, T, Rovira, J, De Ciurana, M, Xargay, C, Cortés, RB, Paredes, J, Olive, JG, Montoya, P, El Hosn-Makarem, JA, Pelaez, F, Ubieto, A, Burcet, FX, Alcantarilla, D, De Ribot, J, Gorgot, MR, Bas, RA, Rosa, MB, Castells, J, Castillo, JA, Benet, JM, Caballero, JC, Llach, J, Sanglas, J, Moral, V, Navarro, M, Torrent, JC, Rodríguez, D, Rius, X, Solanella, J, Fallada, A, Cardona, JI, Ferrer, J, Josa, A, Solís, MJ, Güerri, F, Boj, J, Ramon, C, Caballol, R, Navarro, L, Masqué, J, Murillo, MJ, Llovet, MD, Guinea, I, Juárez, MM, Alvarez, M, Bladé, J, Sánchez Oró, I, Martin, F, Cabré, JJ, Frigola, J, Requena, J, Favà, E, Pinazo, MJ, Ros, M, Borrás, S, Sala, J, Nolla, C, Bitrià, J, Araujo, O, Alonso, M, Glaria, T, Chacon, A, Satué, E, Collado, A, Llor, L, Montanyés, D, Garcia, G, Arasa, MJ, Yoldi, A, Viloria, I, Vallespi, F, Clua, JLL, Basart, JM, Ciurana, E, Monclus, JF, Casanovas, A, Viñas, L, Checa, E, Marin, J, Santigosa, J, Basora, T, Gallego, F, Martin, E, Gil, P, Roselló, M, Arayo, I, Palacios, F, Donado, A, Marimon, J, Costa, B, Gutiérrez, C, Moltó, E, Isach, A, Izzeddin, N, Campani, M, Ferré, J, Fernández, A, Jové, J, Vilalta, J, Ribera, E, Fernández, M, Ochoa, O, Vila, A, Pujol, J, Navarro, MA, Campillos, C, Juarez, A, Perez, J, Casado, I, Paredes, E, Rodriguez, J, Vazquez, A, Solà, Y, Berdié, J, Andrés, MJ, Barragan, B, Torras, A, Madrid, M, Gonzalez, S, Fuentes, A, Iñiguez, M, Guasch, J, Sánchez, F, Pascual, J, Castelló, A, Gómez, L, Mateu, C, Arranz, J, Fé, A, Puig, B, Gutiérrez, M, Morant, L, Llull, M, Estelrich, J, Quintana, L, Llabrés, C, Sureda, MM, Cuevas, L, Muñoz, Y, Llobera, J, Marin, P, Garcia, C, Moreno, P, Coll, M, Palma, C, Ribera, C, Aldosa, J, Alonso, C, Bergés, A, Burgués, J, Burgués, L, Busquets, J, Casal, D, Cerdán, N, Crespo, X, Duat, R, Escoda, J, Fiter, M, Font, A, Fraysse, M, Fuentes, S, García-Núñez, R, López-Pinacho, T, Masardo, M, Martínez-Illescas, J, Morisset, P, Pallarés, M, Pérez-Serra, R, Plà, A, Pons, E, Ruiz, A, Rodríguez-Picart, JC, Sánchez-Claver, J, Sylvestre, E, Tolosa, R, Touceda, JA, Varela, JR, Vidal, JC, Amate, M, Bara, C, Becerra, O, Bellmunt, R, Boneu, F, Bozal, J, Burillo, C, Díaz, A, González, N, Granyena, A, Gutiérrez, M, Infante, C, Leal, M, Linares, M, Magallón, J, Marqués, J, Martí, MJ, Miralles, JC, Mora, C, Palacín, JM, Pons, J, Prats, G, Pujal, G, Sanjuán, M, Segarra, X, Solís, J, Trelles, H, De Celis, G, Latorre, X, Sarroca, O & Briceño, H 2010, 'Inhaled drugs as risk factors for communityacquired pneumonia', European Respiratory Journal, vol. 36, núm. 5, pàg. 1080-1087. https://doi.org/10.1183/09031936.00022909

TY - JOUR

T1 - Inhaled drugs as risk factors for communityacquired pneumonia

AU - Almirall, J.

AU - Bolíbar, I.

AU - Serra-Prat, M.

AU - Palomera, E.

AU - Roig, J.

AU - Hospital, I.

AU - Carandelle, E.

AU - Agustí, M.

AU - Ayuso, P.

AU - Estela, A.

AU - Torres, A.

AU - De Salas, J. M.

AU - Costa, J.

AU - Tristany, M.

AU - Grau, M. J.

AU - Sancho, S.

AU - Miguel, E.

AU - Fradera, M.

AU - Ochoa, I.

AU - Castany, M. J.

AU - Quilez, A.

AU - Marina, V.

AU - Subias, P.

AU - Jimeno, B.

AU - Bradnovich,

AU - Rodriguez, M.

AU - Ramon, E.

AU - Gardella, A.

AU - Ginés, C.

AU - Montero, J. C.

AU - Flores, P.

AU - Serra, P.

AU - Torrellas, E.

AU - Serrano, C.

AU - Pubill, M.

AU - Gost, J.

AU - Buxadé, I.

AU - Mussoll, J.

AU - Mestres, X.

AU - Armada, A.

AU - Mallafré, J.

AU - Roger, M.

AU - Gros, M. T.

AU - Les, N.

AU - Joanola, J.

AU - Doménech, J.

AU - Bundó, M.

AU - Trilla, M.

AU - Massons, J.

AU - Montero, J.

AU - Zurilla, E.

AU - Alegre, M.

AU - Papiol, M.

AU - Martí, O.

AU - Catalá, M.

AU - Martinez, M. A.

AU - Casanovas, A.

AU - Beisani, I.

AU - Tria, C.

AU - Diaz, E.

AU - Torán, P.

AU - Aizpurua, M. M.

AU - Lozano, G.

AU - Casals, J.

AU - Sorribes, J.

AU - Torrellas, D.

AU - Casas, A.

AU - Bernad, J.

AU - De Montoliu, A.

AU - Gaya, J.

AU - Vallés, R.

AU - Vazquez, A.

AU - Peiró, R.

AU - Aresté, G.

AU - Mengual, G. N.

AU - Viñes, M. C.

AU - Almerich, E.

AU - Lopez, M. A.

AU - Bel, J.

AU - Gosalves, A.

AU - Macip, S.

AU - Carrillo, E.

AU - Paulo, P.

AU - Pol, M.

AU - Sala, J.

AU - Mir, P.

AU - Anglada, J. L.L.

AU - Salabarnada, J.

AU - Sanz, E.

AU - Gorgas, F.

AU - Ribas, A.

AU - Fau, E.

AU - Pellicer, I.

AU - Morales, S.

AU - Burdoy, E.

AU - Bartolomé, M.

AU - Corona, E.

AU - Mateu, L.

AU - Paret, M.

AU - Verde, Y.

AU - Borrás, A.

AU - Aznar, F.

AU - Riera, F.

AU - Vazquez, A.

AU - Gil, P.

AU - Colom, I.

AU - Calvet, E.

AU - Nicolás, J.

AU - Ruiz, J.

AU - Carrera, P.

AU - Legazpi, I.

AU - Planellas, F.

AU - Beltran, A.

AU - Planas, T.

AU - Rovira, J.

AU - De Ciurana, M.

AU - Xargay, C.

AU - Cortés, R. B.

AU - Paredes, J.

AU - Olive, J. G.

AU - Montoya, P.

AU - El Hosn-Makarem, J. A.

AU - Pelaez, F.

AU - Ubieto, A.

AU - Burcet, F. X.

AU - Alcantarilla, D.

AU - De Ribot, J.

AU - Gorgot, M. R.

AU - Bas, R. A.

AU - Rosa, M. B.

AU - Castells, J.

AU - Castillo, J. A.

AU - Benet, J. M.

AU - Caballero, J. C.

AU - Llach, J.

AU - Sanglas, J.

AU - Moral, V.

AU - Navarro, M.

AU - Torrent, J. C.

AU - Rodríguez, D.

AU - Rius, X.

AU - Solanella, J.

AU - Fallada, A.

AU - Cardona, J. I.

AU - Ferrer, J.

AU - Josa, A.

AU - Solís, M. J.

AU - Güerri, F.

AU - Boj, J.

AU - Ramon, C.

AU - Caballol, R.

AU - Navarro, L.

AU - Masqué, J.

AU - Murillo, M. J.

AU - Llovet, M. D.

AU - Guinea, I.

AU - Juárez, M. M.

AU - Alvarez, M.

AU - Bladé, J.

AU - Sánchez Oró, I.

AU - Martin, F.

AU - Cabré, J. J.

AU - Frigola, J.

AU - Requena, J.

AU - Favà, E.

AU - Pinazo, M. J.

AU - Ros, M.

AU - Borrás, S.

AU - Sala, J.

AU - Nolla, C.

AU - Bitrià, J.

AU - Araujo, O.

AU - Alonso, M.

AU - Glaria, T.

AU - Chacon, A.

AU - Satué, E.

AU - Collado, A.

AU - Llor, Ll

AU - Montanyés, D.

AU - Garcia, G.

AU - Arasa, M. J.

AU - Yoldi, A.

AU - Viloria, I.

AU - Vallespi, F.

AU - Clua, J. L.L.

AU - Basart, J. M.

AU - Ciurana, E.

AU - Monclus, J. F.

AU - Casanovas, A.

AU - Viñas, L.

AU - Checa, E.

AU - Marin, J.

AU - Santigosa, J.

AU - Basora, T.

AU - Gallego, F.

AU - Martin, E.

AU - Gil, P.

AU - Roselló, M.

AU - Arayo, I.

AU - Palacios, F.

AU - Donado, A.

AU - Marimon, J.

AU - Costa, B.

AU - Gutiérrez, C.

AU - Moltó, E.

AU - Isach, A.

AU - Izzeddin, N.

AU - Campani, M.

AU - Ferré, J.

AU - Fernández, A.

AU - Jové, J.

AU - Vilalta, J.

AU - Ribera, E.

AU - Fernández, M.

AU - Ochoa, O.

AU - Vila, A.

AU - Pujol, J.

AU - Navarro, M. A.

AU - Campillos, C.

AU - Juarez, A.

AU - Perez, J.

AU - Casado, I.

AU - Paredes, E.

AU - Rodriguez, J.

AU - Vazquez, A.

AU - Solà, Y.

AU - Berdié, J.

AU - Andrés, M. J.

AU - Barragan, B.

AU - Torras, A.

AU - Madrid, M.

AU - Gonzalez, S.

AU - Fuentes, A.

AU - Iñiguez, M.

AU - Guasch, J.

AU - Sánchez, F.

AU - Pascual, J.

AU - Castelló, A.

AU - Gómez, Ll

AU - Mateu, C.

AU - Arranz, J.

AU - Fé, A.

AU - Puig, B.

AU - Gutiérrez, M.

AU - Morant, Ll

AU - Llull, M.

AU - Estelrich, J.

AU - Quintana, L.

AU - Llabrés, C.

AU - Sureda, M. M.

AU - Cuevas, L.

AU - Muñoz, Y.

AU - Llobera, J.

AU - Marin, P.

AU - Garcia, C.

AU - Moreno, P.

AU - Coll, M.

AU - Palma, C.

AU - Ribera, C.

AU - Aldosa, J.

AU - Alonso, C.

AU - Bergés, A.

AU - Burgués, J.

AU - Burgués, Ll

AU - Busquets, J.

AU - Casal, D.

AU - Cerdán, N.

AU - Crespo, X.

AU - Duat, R.

AU - Escoda, J.

AU - Fiter, M.

AU - Font, A.

AU - Fraysse, M.

AU - Fuentes, S.

AU - García-Núñez, R.

AU - López-Pinacho, T.

AU - Masardo, M.

AU - Martínez-Illescas, J.

AU - Morisset, P.

AU - Pallarés, M.

AU - Pérez-Serra, R.

AU - Plà, A.

AU - Pons, E.

AU - Ruiz, A.

AU - Rodríguez-Picart, J. C.

AU - Sánchez-Claver, J.

AU - Sylvestre, E.

AU - Tolosa, R.

AU - Touceda, J. A.

AU - Varela, J. R.

AU - Vidal, J. C.

AU - Amate, M.

AU - Bara, C.

AU - Becerra, O.

AU - Bellmunt, R.

AU - Boneu, F.

AU - Bozal, J.

AU - Burillo, C.

AU - Díaz, A.

AU - González, N.

AU - Granyena, A.

AU - Gutiérrez, M.

AU - Infante, C.

AU - Leal, M.

AU - Linares, M.

AU - Magallón, J.

AU - Marqués, J.

AU - Martí, M. J.

AU - Miralles, J. C.

AU - Mora, C.

AU - Palacín, J. M.

AU - Pons, J.

AU - Prats, G.

AU - Pujal, G.

AU - Sanjuán, M.

AU - Segarra, X.

AU - Solís, J.

AU - Trelles, H.

AU - De Celis, G.

AU - Latorre, X.

AU - Sarroca, O.

AU - Briceño, H.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - The effect of inhaled drugs in community-acquired pneumonia (CAP) is unclear. This case-control study was designed to determine whether inhaled drugs were risk factors for CAP. All incident cases of confirmed CAP that occurred over 1 yr in patients with chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD) or asthma were included, as well as CB, COPD and asthma controls. Risk factors for CAP and inhaled treatment were recorded during a personal interview. An effect of inhaled drugs on the risk of CAP was observed in COPD and asthma patients after adjusting for the effect of other respiratory diseases and their concomitant treatments. In COPD patients, inhaled steroids had a risk OR of 3.26 (95% CI 1.07-9.98) and in asthma patients inhaled anticholinergics had a risk OR of 8.80 (95% CI 1.02-75.7). In CB patients, no association with CAP was observed for any inhaler. These effects were independent of adjusting variables related to severity and other respiratory and non-respiratory risk factors for CAP, including vaccines. Inhaled β2-adrenergic agonists did not show a significant effect on the risk of CAP in any of the respiratory diseases. Inhaled steroids may favour CAP in COPD patients, whereas anticholinergics may favour CAP in asthma patients. It is difficult to differentiate the effect of inhaled therapy from the effect of COPD or asthma severity on the risk of CAP, and these relationships may not be causal, but could call attention to inhaled therapy in COPD and asthma patients. Copyright

AB - The effect of inhaled drugs in community-acquired pneumonia (CAP) is unclear. This case-control study was designed to determine whether inhaled drugs were risk factors for CAP. All incident cases of confirmed CAP that occurred over 1 yr in patients with chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD) or asthma were included, as well as CB, COPD and asthma controls. Risk factors for CAP and inhaled treatment were recorded during a personal interview. An effect of inhaled drugs on the risk of CAP was observed in COPD and asthma patients after adjusting for the effect of other respiratory diseases and their concomitant treatments. In COPD patients, inhaled steroids had a risk OR of 3.26 (95% CI 1.07-9.98) and in asthma patients inhaled anticholinergics had a risk OR of 8.80 (95% CI 1.02-75.7). In CB patients, no association with CAP was observed for any inhaler. These effects were independent of adjusting variables related to severity and other respiratory and non-respiratory risk factors for CAP, including vaccines. Inhaled β2-adrenergic agonists did not show a significant effect on the risk of CAP in any of the respiratory diseases. Inhaled steroids may favour CAP in COPD patients, whereas anticholinergics may favour CAP in asthma patients. It is difficult to differentiate the effect of inhaled therapy from the effect of COPD or asthma severity on the risk of CAP, and these relationships may not be causal, but could call attention to inhaled therapy in COPD and asthma patients. Copyright

KW - Community-acquired pneumonia

KW - Inhaled drug treatment

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=78349272090&partnerID=8YFLogxK

U2 - 10.1183/09031936.00022909

DO - 10.1183/09031936.00022909

M3 - Article

C2 - 20525710

AN - SCOPUS:78349272090

SN - 0903-1936

VL - 36

SP - 1080

EP - 1087

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 5

ER -

Inhaled drugs as risk factors for communityacquired pneumonia

Resum

SDG de les Nacions Unides

Accés al document

Altres arxius i enllaços

Fingerprint

Com citar-ho