Resum
The influence of diverse carboxylic acid on the preparation of chlorohydrin esters using a one-pot esterification-chlorination reaction, in which one of the reagents (chlorotrimethylsilane) acts as solvent, is described. Whereas the acid with low pKa provided higher amounts of the 2-chloro regioisomer, the ones with higher pKa rendered the 1-chloro regioisomer in 80% yield. These results are in accordance with the mechanism proposed in a previous article.
Idioma original | Anglès |
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Pàgines (de-a) | 1167-1175 |
Nombre de pàgines | 9 |
Revista | Synthetic Communications |
Volum | 36 |
Número | 9 |
DOIs | |
Estat de la publicació | Publicada - 2006 |
Publicat externament | Sí |