TY - JOUR
T1 - Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
AU - Solans, Marta
AU - Benavente, Yolanda
AU - Saez, Marc
AU - Agudo, Antonio
AU - Jakszyn, Paula
AU - Naudin, Sabine
AU - Hosnijeh, Fatemeh Saberi
AU - Gunter, Marc
AU - Huybrechts, Inge
AU - Ferrari, Pietro
AU - Besson, Caroline
AU - Mahamat-Saleh, Yahya
AU - Boutron-Ruault, Marie Christine
AU - Kühn, Tilman
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Lasheras, Cristina
AU - Sánchez, Maria Jose
AU - Amiano, Pilar
AU - Chirlaque, María Dolores
AU - Ardanaz, Eva
AU - Schmidt, Julie A.
AU - Vineis, Paolo
AU - Riboli, Elio
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Valanou, Elisavet
AU - Masala, Giovanna
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Mattiello, Amalia
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Jerkeman, Mats
AU - Dias, Joana Alves
AU - Späth, Florentin
AU - Nilsson, Lena Maria
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Petersen, Kristina Elin Nielsen
AU - Tjønneland, Anne
AU - de Sanjose, Silvia
AU - Vermeulen, Roel
AU - Nieters, Alexandra
AU - Casabonne, Delphine
N1 - Funding Information:
We thank all participants of the EPIC study. We thank Catalina Bonet for data management support and Bertrand Hémon at IARC for his valuable work and technical support with the EPIC database.
Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.
AB - Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.
KW - Chronic inflammation
KW - Inflammatory score of the diet
KW - Lymphoma
KW - Nutrition
KW - Prospective studies
UR - http://www.scopus.com/inward/record.url?scp=85064081118&partnerID=8YFLogxK
U2 - 10.1007/s00394-019-01947-0
DO - 10.1007/s00394-019-01947-0
M3 - Article
C2 - 30903361
AN - SCOPUS:85064081118
SN - 1436-6207
VL - 59
SP - 813
EP - 823
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 2
ER -
