Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds

Medicine and Dentistry

• Cancer Cell 100%
• Pancreas Cancer 100%
• Focal Adhesion Kinase 100%
• Janus Kinase 1 100%
• Neoplasm 50%
• In Vitro 33%
• Signal Transduction 33%
• Malignant Neoplasm 16%
• Biological Phenomena and Functions Concerning the Entire Organism 16%
• Cell Proliferation 16%
• down Regulation 16%
• Cell Survival 16%
• Extracellular Matrix 16%
• Stroma 16%
• Protein Tyrosine Kinase 16%
• Nanofiber 16%
• Solid Malignant Neoplasm 16%
• Pancreas Adenocarcinoma 16%
• Collagen Type 1 16%
• Cancer 16%
• Angiogenesis 16%
• Protein Kinase 16%
• Cell Culture 16%
• Cell Migration 16%
• Integrin 16%
• Cell Line 16%
• Autophosphorylation 16%

Biochemistry, Genetics and Molecular Biology

• Self-Assembling Peptide 100%
• Cancer Cell 100%
• Rigidity 100%
• Janus Kinase 1 100%
• Signal Transduction 25%
• Cell Migration 12%
• Type I Collagen 12%
• Degradation in Vitro 12%
• Non-Receptor Tyrosine Kinase 12%
• Cell Survival 12%
• Cell Culture 12%
• Cell Proliferation 12%
• Biological Phenomena and Functions Concerning the Entire Organism 12%
• Downregulation 12%
• Angiogenesis 12%
• Autophosphorylation 12%
• Integrin 12%

Engineering

• Matrix Stiffness 100%
• Microenvironments 25%
• Collagen Type 25%
• Nanofibers 25%
• Cell Response 25%
• Protein Level 25%
• Downregulation 25%