Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain

Jordi Duran, Isabel Saez, Agnès Gruart, Joan J. Guinovart, José M. Delgado-García

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118 Cites (Scopus)

Resum

Glycogen is the only carbohydrate reserve of the brain, but its overall contribution to brain functions remains unclear. Although it has traditionally been considered as an emergency energetic reservoir, increasing evidence points to a role of glycogen in the normal activity of the brain. To address this long-standing question, we generated a brain-specific Glycogen Synthase knockout (GYS1Nestin-KO) mouse and studied the functional consequences of the lack of glycogen in the brain under alert behaving conditions. These animals showed a significant deficiency in the acquisition of an associative learning task and in the concomitant activity-dependent changes in hippocampal synaptic strength. Long-term potentiation (LTP) evoked in the hippocampal CA3-CA1 synapse was also decreased in behaving GYS1Nestin-KO mice. These results unequivocally show a key role of brain glycogen in the proper acquisition of new motor and cognitive abilities and in the underlying changes in synaptic strength.

Idioma originalAnglès
Pàgines (de-a)550-556
Nombre de pàgines7
RevistaJournal of Cerebral Blood Flow and Metabolism
Volum33
Número4
DOIs
Estat de la publicacióPublicada - d’abr. 2013
Publicat externament

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