Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

Emilia Sánchez Ruiz; Clàudia Fortuny; Antoni  Noguera-Julián; Laia Alsina; Rocío Bellido; Carmen Muñoz-Almagro; Lidia Ruiz

Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

Emilia Sánchez Ruiz
, Clàudia Fortuny
, Antoni Noguera-Julián
, Laia Alsina
, Rocío Bellido
, Carmen Muñoz-Almagro
, Lidia Ruiz

Facultat de Ciències de la Salut Blanquerna

Producció científica: Article en revista indexada › Article › Avaluat per experts

Resum

The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off
point of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).

Idioma original	Anglès
Pàgines (de-a)	426-428
Nombre de pàgines	3
Revista	Pediatric Infectious Disease Journal
Volum	30
Número	5
Estat de la publicació	Publicada - 1 de maig 2011

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

ODS 3 Salut i benestar

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https://journals.lww.com/pidj/Fulltext/2011/05000/IMPACT_OF_CD4_T_CELL_COUNT_ON_THE_OUTCOME_OF.21.aspxLlicència: CC BY-NC-ND

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Sánchez Ruiz, E., Fortuny, C., Noguera-Julián, A., Alsina, L., Bellido, R., Muñoz-Almagro, C., & Ruiz, L. (2011). Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children. Pediatric Infectious Disease Journal, 30(5), 426-428. https://journals.lww.com/pidj/Fulltext/2011/05000/IMPACT_OF_CD4_T_CELL_COUNT_ON_THE_OUTCOME_OF.21.aspx

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title = "Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children",

abstract = "The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off point of 5 mm indicates excellent sensitivity (100\%) and specificity (93\%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86\%), and a cut-off point of 15 mm resulted in reduced sensitivity (60\%).",

keywords = "Tuberculosis, Sensitivity, Tuberculin skin test, Interferon-gamma release assays",

author = "\{S{\'a}nchez Ruiz\}, Emilia and Cl{\`a}udia Fortuny and Antoni Noguera-Juli{\'a}n and Laia Alsina and Roc{\'i}o Bellido and Carmen Mu{\~n}oz-Almagro and Lidia Ruiz",

note = "Fortuny C; Noguera A; Alsina L; Bellido R; S{\'a}nchez E; Mu{\~n}oz-Almagro C; Ruiz L; Jim{\'e}nez R. Supported by Fondo de Investigaci{\'o}n Sanitaria (FIS 99/0051-01). Supported by Pedro Pons Grant, Universitat de Barcelona (to L.A.).",

year = "2011",

month = may,

day = "1",

language = "English",

volume = "30",

pages = "426--428",

journal = "Pediatric Infectious Disease Journal",

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publisher = "Lippincott Williams and Wilkins",

number = "5",

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Sánchez Ruiz, E, Fortuny, C, Noguera-Julián, A, Alsina, L, Bellido, R, Muñoz-Almagro, C & Ruiz, L 2011, 'Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children', Pediatric Infectious Disease Journal, vol. 30, núm. 5, pàg. 426-428. <https://journals.lww.com/pidj/Fulltext/2011/05000/IMPACT_OF_CD4_T_CELL_COUNT_ON_THE_OUTCOME_OF.21.aspx>

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AU - Sánchez Ruiz, Emilia

AU - Fortuny, Clàudia

AU - Noguera-Julián, Antoni

AU - Alsina, Laia

AU - Bellido, Rocío

AU - Muñoz-Almagro, Carmen

AU - Ruiz, Lidia

N1 - Fortuny C; Noguera A; Alsina L; Bellido R; Sánchez E; Muñoz-Almagro C; Ruiz L; Jiménez R. Supported by Fondo de Investigación Sanitaria (FIS 99/0051-01). Supported by Pedro Pons Grant, Universitat de Barcelona (to L.A.).

PY - 2011/5/1

Y1 - 2011/5/1

N2 - The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off point of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).

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KW - Sensitivity

KW - Tuberculin skin test

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Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

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