TY - JOUR
T1 - Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children
AU - Sánchez Ruiz, Emilia
AU - Fortuny, Clàudia
AU - Noguera-Julián, Antoni
AU - Alsina, Laia
AU - Bellido, Rocío
AU - Muñoz-Almagro, Carmen
AU - Ruiz, Lidia
N1 - Fortuny C; Noguera A; Alsina L; Bellido R; Sánchez E; Muñoz-Almagro C; Ruiz L; Jiménez R. Supported by Fondo de Investigación Sanitaria (FIS 99/0051-01). Supported by Pedro Pons Grant, Universitat de Barcelona (to L.A.).
PY - 2011/5/1
Y1 - 2011/5/1
N2 - The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-offpoint of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).
AB - The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-offpoint of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).
KW - Tuberculosis
KW - Sensitivity
KW - Tuberculin skin test
KW - Interferon-gamma release assays
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-80051943538&origin=resultslist&sort=plf-f&src=s&sid=50786f8253e00ca1f550220425f77088&sot=b&sdt=b&s=TITLE-ABS-KEY%28Impact+of+human+immunodeficiency+virus+coinfection+on+the+progression+of+mother-to-child+transmitted+hepatitis+C+virus+infection%29&sl=143&sessionSearchId=50786f8253e00ca1f550220425f77088
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000294044400022
M3 - Article
SN - 0891-3668
VL - 30
SP - 426
EP - 428
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 5
ER -
