Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Josep Sauri; Wolfgang Bermel; Alexei V. Buevich; Edward C. Sherer; Leo A. Joyce; Maged H. M. Sharaf; Paul L. Schiff; Teodor Parella; R. Thomas Williamson; Gary E. Martin

doi:10.1002/anie.201502540

Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Josep Sauri, Wolfgang Bermel, Alexei V. Buevich, Edward C. Sherer, Leo A. Joyce, Maged H. M. Sharaf, Paul L. Schiff, Teodor Parella, R. Thomas Williamson, Gary E. Martin

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Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.

Idioma original	Anglès
Pàgines (de-a)	10160-10164
Nombre de pàgines	5
Revista	Angewandte Chemie - International Edition
Volum	54
Número	35
DOIs	https://doi.org/10.1002/anie.201502540
Estat de la publicació	Publicada - 24 d’ag. 2015
Publicat externament	Sí

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title = "Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine",

abstract = "Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.",

keywords = "DFT calculations, Hd-adequate, NMR spectroscopy, Cryptolepis alkaloids, Homodecoupling",

author = "Josep Sauri and Wolfgang Bermel and Buevich, \{Alexei V.\} and Sherer, \{Edward C.\} and Joyce, \{Leo A.\} and Sharaf, \{Maged H. M.\} and Schiff, \{Paul L.\} and Teodor Parella and Williamson, \{R. Thomas\} and Martin, \{Gary E.\}",

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T2 - Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

AU - Sauri, Josep

AU - Bermel, Wolfgang

AU - Buevich, Alexei V.

AU - Sherer, Edward C.

AU - Joyce, Leo A.

AU - Sharaf, Maged H. M.

AU - Schiff, Paul L.

AU - Parella, Teodor

AU - Williamson, R. Thomas

AU - Martin, Gary E.

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AB - Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.

KW - DFT calculations

KW - Hd-adequate

KW - NMR spectroscopy

KW - Cryptolepis alkaloids

KW - Homodecoupling

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JO - Angewandte Chemie - International Edition

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Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

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