Genetically encoded singlet oxygen photosensitizers

Títol traduït de la contribució: Chapter 13 Genetically encoded singlet oxygen photosensitizers

Ruben Ruiz Gonzalez, Alberto Rodríguez-Pulido, Joaquim Torra, Santiago Nonell Marrugat, Cristina Flors

Producció científica: Capítol de llibreCapítolAvaluat per experts

Resum

The ability to selectively control the site of singlet-oxygen (1O2) production in a cell is crucial for inflicting photodynamic damage in a desired location. Genetically encoded photosensitizers, which can be fused to virtually any protein and are expressed in a cell without the need to add any external cofactors, offer absolute control of the 1O2 production site. This chapter provides a molecular view of the photosensitization mechanisms in two families of genetically encoded photosensitizers: green fluorescent protein variants and flavoproteins. It also covers the main applications of these proteins in areas such as photodynamic therapy and chromophore-assisted laser inactivation, as well as in advanced imaging techniques.
Títol traduït de la contribucióChapter 13 Genetically encoded singlet oxygen photosensitizers
Idioma originalAnglès
Títol de la publicacióSinglet Oxygen. Applications in Biosciences and Nanosciences
EditorsSanti Nonell, Cristina Flors
EditorRoyal Society of Chemistry
Capítol13
Pàgines271-286
Nombre de pàgines15
Volum1
ISBN (electrònic)978-1-78262-801-9, 978-1-78262-220-8
ISBN (imprès)978-1-78262-038-9
DOIs
Estat de la publicacióPublicada - de gen. 2016

Sèrie de publicacions

NomComprehensive Series in Photochemical & Photobiological Sciences
ISSN (imprès)2041-9716
ISSN (electrònic)2041-9724

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