Resum
In the present Letter, a fast, automated, and reproducible method for the synthesis of S-[13N]nitrosothiols is reported. The labeling strategy is based on trapping [13 N] NO2- in an anion exchange resin. The reaction with thiols in acidic media led to the formation of the desired nitrosothiols in short reaction times (60 s) with excellent radiochemical conversions (from 48.7% to 74.5%). Final radiotracers were purified by HPLC. Good radiochemical yields (from 33.8% to 60.6%, decay corrected) and radiochemical purities (>99%) were obtained in all cases. Stability of the labeled compounds was checked.
Idioma original | Anglès |
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Pàgines (de-a) | 2990-2993 |
Nombre de pàgines | 4 |
Revista | Tetrahedron Letters |
Volum | 51 |
Número | 22 |
DOIs | |
Estat de la publicació | Publicada - 2 de juny 2010 |