Fully automated synthesis of 13N-labeled nitrosothiols

Vanessa Gómez-Vallejo, Koichi Kato, Iosu Oliden, Javier Calvo, Zuriñe Baz, José I. Borrell, Jordi Llop

Producció científica: Article en revista indexadaArticleAvaluat per experts

12 Cites (Scopus)


In the present Letter, a fast, automated, and reproducible method for the synthesis of S-[13N]nitrosothiols is reported. The labeling strategy is based on trapping [13 N] NO2- in an anion exchange resin. The reaction with thiols in acidic media led to the formation of the desired nitrosothiols in short reaction times (60 s) with excellent radiochemical conversions (from 48.7% to 74.5%). Final radiotracers were purified by HPLC. Good radiochemical yields (from 33.8% to 60.6%, decay corrected) and radiochemical purities (>99%) were obtained in all cases. Stability of the labeled compounds was checked.

Idioma originalAnglès
Pàgines (de-a)2990-2993
Nombre de pàgines4
RevistaTetrahedron Letters
Estat de la publicacióPublicada - 2 de juny 2010


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