TY - JOUR
T1 - Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Rohrmann, Sabine
AU - Becker, Nikolaus
AU - Linseisen, Jakob
AU - Nieters, Alexandra
AU - Rüdiger, Thomas
AU - Raaschou-Nielsen, Ole
AU - Tjønneland, Anne
AU - Johnsen, Hans E.
AU - Overvad, Kim
AU - Kaaks, Rudolf
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Benetou, Vasiliki
AU - Psaltopoulou, Theodora
AU - Trichopoulou, Antonia
AU - Masala, Giovanna
AU - Mattiello, Amalia
AU - Krogh, Vittorio
AU - Tumino, Rosario
AU - Gils, Carla H.Van
AU - Peeters, Petra H.M.
AU - Bueno-De-Mesquita, H. Bas
AU - Ros, Martine M.
AU - Lund, Eiliv
AU - Ardanaz, Eva
AU - Chirlaque, María Dolores
AU - Jakszyn, Paula
AU - Larrañaga, Nerea
AU - Losada, A.
AU - Martínez-García, Carmen
AU - Ågren, Åsa
AU - Hallmans, Göran
AU - Berglund, Göran
AU - Manjer, Jonas
AU - Allen, Naomi E.
AU - Key, Timothy J.
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Slimani, Nadia
AU - Ferrari, Pietro
AU - Boffetta, Paolo
AU - Norat, Teresa
AU - Vineis, Paolo
AU - Riboli, Elio
N1 - Funding Information:
The work described in this article was carried out with the financial support of: Europe Against Cancer Program of the European Commission (SANCO); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturia, Basque Country, Murcia and Navarra; the ISCIII Network RCESP (C03/09), Spain; Cancer Research UK; Medical Research Council, United Kingdom; Stroke Association, United Kingdom; British Heart Foundation; Department of Health, United Kingdom; Food Standards Agency, United Kingdom; Wellcome Trust, United Kingdom; Greek Ministry of Health; Greek Ministry of Education; Italian Association for Research on Cancer (AIRC); Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy; Compagnia di San Paolo; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skåne, Sweden; Norwegian Cancer Society; Research Council of Norway; French League against Cancer (LNCC); National Institute for Health and Medical Research (INSERM), France; Mutuelle Générale de l’Education Nationale (MGEN), France; 3M Co, France; Gustave Roussy Institute (IGR), France; and General Councils of France.
PY - 2007/6
Y1 - 2007/6
N2 - Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.
AB - Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.
KW - Cohort study
KW - Fruits
KW - Hodgkin lymphoma
KW - Non-Hodgkin lymphoma
KW - Vegetables
UR - http://www.scopus.com/inward/record.url?scp=34247625528&partnerID=8YFLogxK
U2 - 10.1007/s10552-007-0125-z
DO - 10.1007/s10552-007-0125-z
M3 - Article
C2 - 17443415
AN - SCOPUS:34247625528
SN - 0957-5243
VL - 18
SP - 537
EP - 549
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 5
ER -
