From venoms to BBB-shuttles. MiniCTX3: A molecular vector derived from scorpion venom

Cristina Díaz-Perlas; Monica Varese; Salvador Guardiola; Jesús García; Macarena Sánchez-Navarro; Ernest Giralt; Meritxell Teixidó

doi:10.1039/c8cc06725b

From venoms to BBB-shuttles. MiniCTX3: A molecular vector derived from scorpion venom

Cristina Díaz-Perlas
, Monica Varese
, Salvador Guardiola
, Jesús García
, Macarena Sánchez-Navarro
, Ernest Giralt^*
, Meritxell Teixidó

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

27 Cites (Scopus)

Resum

The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.

Idioma original	Anglès
Pàgines (de-a)	12738-12741
Nombre de pàgines	4
Revista	Chemical Communications
Volum	54
Número	90
DOIs	https://doi.org/10.1039/c8cc06725b
Estat de la publicació	Publicada - 2018
Publicat externament	Sí

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abstract = "The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.",

author = "Cristina D{\'i}az-Perlas and Monica Varese and Salvador Guardiola and Jes{\'u}s Garc{\'i}a and Macarena S{\'a}nchez-Navarro and Ernest Giralt and Meritxell Teixid{\'o}",

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doi = "10.1039/c8cc06725b",

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T1 - From venoms to BBB-shuttles. MiniCTX3

T2 - A molecular vector derived from scorpion venom

AU - Díaz-Perlas, Cristina

AU - Varese, Monica

AU - Guardiola, Salvador

AU - García, Jesús

AU - Sánchez-Navarro, Macarena

AU - Giralt, Ernest

AU - Teixidó, Meritxell

PY - 2018

Y1 - 2018

N2 - The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.

AB - The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.

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From venoms to BBB-shuttles. MiniCTX3: A molecular vector derived from scorpion venom

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