TY - JOUR
T1 - From venoms to BBB-shuttles. MiniCTX3
T2 - A molecular vector derived from scorpion venom
AU - Díaz-Perlas, Cristina
AU - Varese, Monica
AU - Guardiola, Salvador
AU - García, Jesús
AU - Sánchez-Navarro, Macarena
AU - Giralt, Ernest
AU - Teixidó, Meritxell
N1 - Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018
Y1 - 2018
N2 - The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.
AB - The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.
UR - http://www.scopus.com/inward/record.url?scp=85056312059&partnerID=8YFLogxK
U2 - 10.1039/c8cc06725b
DO - 10.1039/c8cc06725b
M3 - Article
C2 - 30357254
AN - SCOPUS:85056312059
SN - 1359-7345
VL - 54
SP - 12738
EP - 12741
JO - Chemical Communications
JF - Chemical Communications
IS - 90
ER -