Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study

Berta Diaz-Feijoo, Nuria Agusti-Garcia, Raquel Sebio, Antonio López-Hernández, Marina Sisó, Ariel Glickman, Nuria Carreras-Dieguez, Pere Fuste, Tiermes Marina, Judit Martínez-Egea, Laura Aguilera, Juan Perdomo, Amaia Pelaez, Manuel López-Baamonde, Ricard Navarro-Ripoll, Elena Gimeno, Betina Campero, Aureli Torné, Graciela Martinez-Palli, María J. Arguis

Producció científica: Article en revista indexadaArticleAvaluat per experts

14 Cites (Scopus)

Resum

Introduction: Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before surgery have demonstrated efficacy in postoperative outcomes in non-gynaecological surgeries. However, the viability and effects of these programmes on patients with AOC are unknown. We aimed to evaluate the feasibility and postoperative impact of a multimodal prehabilitation programme in AOC patients undergoing surgery. Methods: This single-centre, before-and-after intervention pilot study included 34 patients in two cohorts: the prehabilitation cohort prospectively included 15 patients receiving supervised exercise, nutritional optimisation, and psychological preparation from December 2019 to January 2021; the control cohort included 19 consecutive patients between January 2018 and November 2019. Enhanced Recovery After Surgery guidelines were followed. Results: The overall adherence to the multimodal prehabilitation programme was 80%, with 86.7% adherence to exercise training, 100% adherence to nutritional optimisation, and 80% adherence to psychological preparation. The median hospital stay was shorter in the prehabilitation cohort (5 (IQR, 4–6) vs. 7 days (IQR, 5–9) in the control cohort, p = 0.04). Differences in postoperative complications using the comprehensive complication index (CCI) were not significant (CCI score: 9.3 (SD 12.12) in the prehabilitation cohort vs. 16.61 (SD 16.89) in the control cohort, p = 0.08). The median time to starting chemotherapy was shorter in the prehabilitation cohort (25 (IQR, 23–25) vs. 35 days (IQR, 28–45) in the control cohort, p = 0.03). Conclusions: A multimodal prehabilitation programme before cytoreductive surgery is feasible in AOC patients with no major adverse effects, and results in significantly shorter hospital stays and time to starting chemotherapy.

Idioma originalAnglès
Número d’article1635
RevistaCancers
Volum14
Número7
DOIs
Estat de la publicacióPublicada - 1 d’abr. 2022
Publicat externament

Fingerprint

Navegar pels temes de recerca de 'Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study'. Junts formen un fingerprint únic.

Com citar-ho