Early intervention (EI) has been shown to be an essential resource for meeting the needs and priorities of children with intellectual and developmental disability and their families. The objective of this study was to examine (a) the perceived quality of life of families attending EI centers in Spain and (b) its relationship with characteristics of the children and their families. The Family Quality of Life Scale was administered to a sample of 281 families with children aged 0 to 6 years attending an EI center. To determine the relationship between family quality of life (FQoL) and the family and children’s characteristics, Student’s t test and one-way ANOVA were performed. Likewise, effect size was measured in those groups. The results show that the emotional well-being of families was high, although they were concerned about health and financial well-being. The perceived FQoL varies depending on income, family type, and severity of the child’s disability. Implications for professional practice in EI centers are presented.