Background: Research evidence from studies in North America on the relationships between family-centered practices, parents’ self-efficacy beliefs, parenting confidence and competence beliefs, and parents’ psychological well-being was used to confirm or disconfirm the same relationships in two studies in Spain. Aims: The aim of Study 1 was to determine if results from studies in North America could be replicated in Spain and the aim of Study 2 was to determine if results from Study 1 could be replicated with a second sample of families in Spain. Methods and procedures: A survey including the study measures was used to obtain data needed to evaluate the relationships among the variables of interest. The participants were 105 family members in Study 1 and 310 family members in Study 2 recruited from nine early childhood intervention programs. Structural equation modeling was used to test the direct and indirect effects of the study variables on parents’ well-being. Outcomes and results: Results showed that family-centered practices were directly related to both self-efficacy beliefs and parenting beliefs, and indirectly related to parents’ psychological well-being mediated by belief appraisals. Conclusion and implications: The pattern of results was similar to those reported in other studies of family-centered practices. Results indicated that the use of family-centered practices can have positive effects on parent well-being beyond that associated with different types of belief appraisals.