Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions

Mary K. S. Batista; Marcal Gallemi; Alberto Adeva; Carlos A. R. Gomes; Paula Gomes

doi:10.1080/00397910802517855

Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions

Mary K. S. Batista, Marcal Gallemi, Alberto Adeva, Carlos A. R. Gomes, Paula Gomes

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Resum

A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.

Idioma original	Anglès
Número d’article	PII 909240030
Pàgines (de-a)	1228-1240
Nombre de pàgines	13
Revista	Synthetic Communications
Volum	39
Número	7
DOIs	https://doi.org/10.1080/00397910802517855
Estat de la publicació	Publicada - 2009
Publicat externament	Sí

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10.1080/00397910802517855

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abstract = "A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.",

keywords = "Antimicrobials, Biopolymers, Chitosan, Diabetes, Drug delivery, Peptides, Pexiganan",

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year = "2009",

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Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions. / Batista, Mary K. S.; Gallemi, Marcal; Adeva, Alberto et al.
In: Synthetic Communications, Vol. 39, Núm. 7, PII 909240030, 2009, pàg. 1228-1240.

Producció científica: Article en revista indexada › Article › Avaluat per experts

TY - JOUR

T1 - Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions

AU - Batista, Mary K. S.

AU - Gallemi, Marcal

AU - Adeva, Alberto

AU - Gomes, Carlos A. R.

AU - Gomes, Paula

PY - 2009

Y1 - 2009

N2 - A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.

AB - A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.

KW - Antimicrobials

KW - Biopolymers

KW - Chitosan

KW - Diabetes

KW - Drug delivery

KW - Peptides

KW - Pexiganan

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JO - Synthetic Communications

JF - Synthetic Communications

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Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions

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